Now showing items 1-10 of 51
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model
(Brain Research, 2015) [Artigo]
Sildenafil (Viagra®) has recently been found to have a neuroprotective effect, which occurs through the inhibition of inflammation and demyelination in the cerebellum. However, the mechanism of action of sildenafil remains ...
Biology of bone tissue: structure, function, and factors that influence bone cells
(BioMed Research International, 2015) [Artigo]
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators ...
Cimetidine-induced Leydig cell apoptosis and reduced EG-VEGF (PK-1) immunoexpression in rats: evidence for the testicular vasculature atrophy
(Reproductive Toxicology (elmsford, N.y.), 2015) [Artigo]
The antiulcer drug cimetidine has shown to cause changes in the testicular microvasculature of adult rats. Since Leydig cells (LCs) produce the pro-angiogenic factor, EG-VEGF (endocrine gland-derived vascular endothelial ...
Nanocomposites based on bacterial cellulose in combination with osteogenic growth peptide for bone repair: cytotoxic, genotoxic and mutagenic evaluations
(Journal of Applied Biology & Biotechnology, 2014) [Artigo]
Bacterial cellulose membranes functionalized with hydroxyapatite or collagen with addition or not of osteogenic growth peptides (OGP) or its C-terminal pentapeptide OGP[10-14] were developed for improving bone repair. The ...
Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice
(Clinical Oral Investigations, 2015-09-28) [Artigo]
To evaluate in long-term periods the destruction of periodontal tissues and bacterial colonization induced by oral gavage with periodontopathogens or ligature experimental periodontal disease models. Forty-eight C57BL/6 J ...
Family-Based Genetic Association for Molar-Incisor Hypomineralization
(Caries Research, 2016-06-01) [Artigo]
Despite some evidence of genetic and environmental factors on molar-incisor hypomineralization (MIH), its aetiology remains unclear. This family-based genetic association study aimed more comprehensively to investigate the ...
Immunolocalization of osteocalcin in matrix-vesicles in the early developing alveolar process of rat molars.
(Molecular Biology Of The Cell, 2015-01-01) [Resumo]
The antineoplastic busulphan impairs peritubular and Leydig cells, and vitamin B-12 stimulates spermatogonia proliferation and prevents busulphan-induced germ cell death
(Biomedicine & Pharmacotherapy, 2017-11-01) [Artigo]
Busulphan (Bu), an alkylating agent used for bone marrow and spermatogonial stem cell transplantation (SSCT), impairs Sertoli (SC) cells, which are necessary for the spermatogonial stem cell (SSC) homing during transplantation. ...
Achados clínicos, genéticos e microbiológicos de uma família com periodontite agressiva de Maceió
(Revista de Odontologia da UNESP, 2010) [Artigo]
The present study reports clinical, microbiological and genetic findings in members of a family with Aggressive Periodontitis (AgP) from Maceió - AL, Brazil. After periodontal exams in fourteen members of the family, DNA ...
Enhanced ERbeta immunoexpression and apoptosis in the germ cells of cimetidine-treated rats
(Reproductive Biology and Endocrinology, 2009-11-18) [Artigo]
Background: Cimetidine, refereed as antiandrogenic drug, causes hormonal changes in male patients such as increased testosterone and FSH levels. In the rat testis, structural alterations in the seminiferous tubules have ...