Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
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Data
2017-10-01
Autores
Chagas Vinhote, Juliana Freire
Lima, Danya Bandeira
Pessoa Bezerra de Menezes, Ramon Roseo Paula
Mello, Clarissa Perdigao
Souza, Bibiana Monson de [UNESP]
Havt, Alexandre
Palma, Mario Sergio [UNESP]
Santos, Ricardo Pires dos
Albuquerque, Eudenilson Lins de
Freire, Valder Nogueira
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Antiparasitic agents, Molecular docking, Wasp venom, Mastoparan
Como citar
Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.