Nanoskin (R) Subcutaneous Implant in Guinea Pigs
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Data
2018-03-01
Autores
Kaminagakura, Kryscia Natsuaki [UNESP]
Sato, Silvana Sue [UNESP]
Sugino, Patricia [UNESP]
Santos, Daniela Carvalho [UNESP]
Kataki, Laryssa [UNESP]
Padovani, Carlos Roberto [UNESP]
Basmaji, Pierre [UNESP]
Schellini, Silvana A. [UNESP]
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Lippincott Williams & Wilkins
Resumo
Purpose: To evaluate the suitability of Nanoskin((R)), a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids. Methods: Forty guinea pigs received a fragment of Nanoskin((R)) subcutaneously in the dorsal region. The animals received Nanoskin((R)) (group 1) or Nanoskin((R)) coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin((R)) was removed for histologic, morphometric, and transmission electron microscopy evaluation. Results: The results were similar for both groups. The subcutaneously implanted Nanoskin((R)) resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule. Conclusion: The good tissue integration of Nanoskin((R)) in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study.
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Ophthalmic Plastic And Reconstructive Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 34, n. 2, p. 136-139, 2018.