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dc.contributor.authorChuffa, Luiz Gustavo A. [UNESP]
dc.contributor.authorSeiva, Fabio R. F. [UNESP]
dc.contributor.authorFavaro, Wagner Jose [UNESP]
dc.contributor.authorTeixeira, Giovana R. [UNESP]
dc.contributor.authorAmorim, Joao P. A. [UNESP]
dc.contributor.authorMendes, Leonardo O. [UNESP]
dc.contributor.authorFioruci, Beatriz A. [UNESP]
dc.contributor.authorPinheiro, Patricia Fernanda F. [UNESP]
dc.contributor.authorFernandes, Ana Angelica H. [UNESP]
dc.contributor.authorFranci, Janete A. A.
dc.contributor.authorDelella, Flávia Karina [UNESP]
dc.contributor.authorMartinez, Marcelo
dc.contributor.authorMartinez, Francisco E. [UNESP]
dc.date.accessioned2014-05-20T13:47:37Z
dc.date.available2014-05-20T13:47:37Z
dc.date.issued2011-08-02
dc.identifierhttp://dx.doi.org/10.1186/1477-7827-9-108
dc.identifier.citationReproductive Biology and Endocrinology. London: Biomed Central Ltd., v. 9, p. 9, 2011.
dc.identifier.issn1477-7827
dc.identifier.urihttp://hdl.handle.net/11449/16944
dc.description.abstractBackground: Melatonin is associated with direct or indirect actions upon female reproductive function. However, its effects on sex hormones and steroid receptors during ovulation are not clearly defined. This study aimed to verify whether exposure to long-term melatonin is able to cause reproductive hormonal disturbances as well as their role on sex steroid receptors in the rat ovary, oviduct and uterus during ovulation.Methods: Twenty-four adult Wistar rats, 60 days old (+/-250 g) were randomly divided into two groups. Control group (Co): received 0.9% NaCl 0.3 mL + 95% ethanol 0.04 mL as vehicle; Melatonin-treated group (MEL): received vehicle + melatonin [ 100 mu g/100 g BW/day] both intraperitoneally during 60 days. All animals were euthanized by decapitation during the morning estrus at 4 a. m.Results: Melatonin significantly reduced the plasma levels of LH and 17 beta-estradiol, while urinary 6-sulfatoximelatonin (STM) was increased at the morning estrus. In addition, melatonin promoted differential regulation of the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and melatonin receptor (MTR) along the reproductive tissues. In ovary, melatonin induced a down-regulation of ER-alpha and PRB levels. Conversely, it was observed that PRA and MT1R were up-regulated. In oviduct, AR and ER-alpha levels were down-regulated, in contrast to high expression of both PRA and PRB. Finally, the ER-beta and PRB levels were down-regulated in uterus tissue and only MT1R was up-regulated.Conclusions: We suggest that melatonin partially suppress the hypothalamus-pituitary-ovarian axis, in addition, it induces differential regulation of sex steroid receptors in the ovary, oviduct and uterus during ovulation.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent9
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofReproductive Biology and Endocrinology
dc.sourceWeb of Science
dc.titleMelatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulationen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, Dept Anat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Inst Biol, Dept Struct & Cellular Biol, BR-13083863 Campinas, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos UFSCar, Dept Morphol & Pathol, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Morphol Stomatol & Physiol, BR-14040900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, Dept Anat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1186/1477-7827-9-108
dc.identifier.wosWOS:000294351200001
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 07/59967-7
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
dc.identifier.fileWOS000294351200001.pdf
dc.identifier.lattes5760560970751598
dc.identifier.orcid0000-0003-1452-5708
unesp.author.lattes5760560970751598[8]
unesp.author.orcid0000-0003-1452-5708[8]
dc.relation.ispartofjcr2.852
dc.relation.ispartofsjr1,203
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