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dc.contributor.authorAraujo, Hygor N.
dc.contributor.authorVictório, Jamaira A.
dc.contributor.authorValgas da Silva, Carmem P. [UNESP]
dc.contributor.authorSponton, Amanda C. S.
dc.contributor.authorVettorazzi, Jean F.
dc.contributor.authorde Moraes, Camila
dc.contributor.authorDavel, Ana P.
dc.contributor.authorZanesco, Angelina
dc.contributor.authorDelbin, Maria A.
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, v. 45, n. 3, p. 293-302, 2018.
dc.description.abstractThe aim of the present study was to evaluate the effects of aerobic exercise training on perivascular adipose tissue (PVAT) function in thoracic aorta from rats fed a high-fat diet. Aortic vascular reactivity was performed in sedentary (SD), trained (TR), sedentary high-fat diet (SD-HF), and trained high-fat diet (TR-HF) male Wistar rats in the absence (PVAT−) or in the presence (PVAT+) of thoracic PVAT. We also measured circulatory concentrations of leptin and tumour necrosis factor alpha (TNF-α), as well as the protein expressions of TNF-α receptor 1 (TNFR1) and inducible nitric oxide synthase (iNOS) on PVAT. In the SD-HF group, the body weight, epididymal fat pad, thoracic PVAT, circulatory triglycerides, insulin, leptin and TNF-α were increased when compared with the SD group, whereas exercise training reduced these values in TR-HF group. The relaxing response curves to acetylcholine and sodium nitroprusside were not modified by either intervention (high-fat diet or exercise training) or the presence of PVAT. The presence of PVAT had an anti-contractile effect in response to serotonin in all groups. In SD-HF group, the increased magnitude of anti-contractile effects was in parallel with an up-regulation of iNOS protein expression in PVAT without alteration in TNFR1. Exercise training was effective in normalizing the vascular reactivity in rings PVAT+ and in reducing the iNOS protein expression. Exercise training prevented the PVAT–induced alteration in thoracic aorta from rats fed a high-fat diet.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology
dc.subjectaerobic exercise training
dc.subjectaortic vascular reactivity
dc.subjecthigh-fat diet
dc.subjectperivascular adipose tissue
dc.titleAnti-contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high-fat diet: role of aerobic exercise trainingen
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Physical Education Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationObesity and Comorbidities Research Center Department of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP)
dc.description.affiliationSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationFaculty of Medicine UNICASTELO
dc.description.affiliationUnespDepartment of Physical Education Institute of Biosciences São Paulo State University (UNESP)
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2013/02960-1
dc.description.sponsorshipIdCNPq: 456051/2014-7
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