Characterization of Atrazine-Loaded Biodegradable Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Microspheres
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Data
2010-03-01
Autores
Grillo, Renato [UNESP]
Melo, Nathalie F. S. de [UNESP]
Lima, Renata de
Lourenço, Roberto Wagner [UNESP]
Rosa, Andre Henrique [UNESP]
Fraceto, Leonardo Fernandes [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer/plenum Publishers
Resumo
Polyhydroxybutyrate-co-hydroxyvalerate microspheres (PHBV-MS) were prepared as a delivery system for the herbicide atrazine (ATZ). Characterization of the system included investigation of in vitro release properties and genotoxicity. ATZ - PHBV-MS particle diameters showed a size distribution range of 1-13 mu m. Differential scanning calorimetry analyses indicated that ATZ was associated with the PHBV microparticles. The release profiles showed a different release behavior for the pure herbicide in solution, as compared with that containing ATZ-loaded PHBV-MS. Korsmeyer-Peppas model analyses showed that atrazine release from the microparticles occurred by a combination of diffusion through the matrix and partial diffusion through water-filled pores of the PHBV microparticles. A Lactuca sativa test result showed that the genotoxicity of ATZ-loaded PHBV-MP was decreased in relation to ATZ alone. The results demonstrate a viable biodegradable herbicide release system using atrazine for agrochemical purposes.
Descrição
Palavras-chave
Atrazine, Pesticide, PHBV, Microspheres, Release system
Como citar
Journal of Polymers and The Environment. New York: Springer/plenum Publishers, v. 18, n. 1, p. 26-32, 2010.