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dc.contributor.authorMattera, Maria Sara De Lima Coutinho [UNESP]
dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorMota, Max Sander De Oliveira Da [UNESP]
dc.contributor.authorPereira, Renato Felipe [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorChaves Neto, Antonio Hernandes [UNESP]
dc.contributor.authorSalzedas, Leda Maria Pescinini [UNESP]
dc.contributor.authorScaramele, Natália Francisco [UNESP]
dc.contributor.authorSilva, Cristina Antoniali [UNESP]
dc.contributor.authorOkamoto, Maristela Mitiko
dc.contributor.authorMachado, Ubiratan Fabres
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.date.accessioned2018-12-11T17:01:12Z
dc.date.available2018-12-11T17:01:12Z
dc.date.issued2016-03-01
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2016.02.010
dc.identifier.citationLife Sciences, v. 148, p. 194-200.
dc.identifier.issn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/11449/172579
dc.description.abstractAims The fetal programming hypothesis suggests that intrauterine stimuli can induce metabolic changes in offspring, increasing the disease risk in adulthood. Periodontal disease may enhance serum cytokine levels. Cytokines such as tumor necrosis factor-alpha (TNF-α) have been associated with reduced glucose transporter type 4 (GLUT4) expression, decreased protein kinase B (Akt) phosphorylation, and insulin resistance. This study aimed to evaluate GLUT4 content, and Akt serine phosphorylation status in the gastrocnemius skeletal muscle (GSM), glycemia, insulinemia and change in body weight in offspring of rats with periodontal disease. Main methods Female Wistar rats were distributed into a control group (CN) and an experimental periodontal disease group (PD), in which a ligature was placed around the mandibular first molars. Seven days after ligature placement, both groups were mated with normal male rats. The ligatures remained throughout pregnancy until weaning, after which the male offspring were distributed into groups: CN-o, control rat offspring; and PD-o, periodontal disease rat offspring. The body weight from 0 to 75 days of age was measured. At 75 days, the glycemia, insulinemia, TNF-α levels, Akt serine phosphorylation, and GLUT4 content in the GSM were measured in the offspring. Key findings The PD-o group showed a low birth weight (LBW), unchanged glycemia, increased insulinemia, insulin resistance, increased TNF-α levels, decreased Akt serine phosphorylation status, and reduced GLUT4 content in the plasma membrane and translocation index after insulin stimulation. Significance Maternal periodontal disease causes LBW, insulin resistance, and alterations in the final stage of insulin signaling in the GSM of adult offspring.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent194-200
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.sourceScopus
dc.subjectDiabetes mellitus
dc.subjectGlucose transporter type 4
dc.subjectLow birth weight
dc.subjectPeriodontal disease
dc.subjectProtein kinase B
dc.titleMaternal periodontitis decreases plasma membrane GLUT4 content in skeletal muscle of adult offspringen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationPrograma de Pos-graduacao Multicentrico em Ciencias Fisiologicas-SBFis Department of Basic Sciences Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.description.affiliationPreventive and Social Dentistry Post-Graduation Program Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.description.affiliationDepartment of Pathology and Clinical Propedeutic Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.description.affiliationDepartment of Physiology and Biophysics São Paulo Institute of Biomedical Sciences USP
dc.description.affiliationUnespPrograma de Pos-graduacao Multicentrico em Ciencias Fisiologicas-SBFis Department of Basic Sciences Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.description.affiliationUnespPreventive and Social Dentistry Post-Graduation Program Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.description.affiliationUnespDepartment of Pathology and Clinical Propedeutic Dental School of Araçatuba Univ Estadual Paulista - UNESP
dc.identifier.doi10.1016/j.lfs.2016.02.010
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2013/08783-4
dc.identifier.scopus2-s2.0-84958974577
dc.identifier.file2-s2.0-84958974577.pdf
unesp.author.orcid0000-0003-3753-229X[12]
dc.relation.ispartofsjr1,071
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