Biocompatibilidade do cimento de fosfato de cálcio implantado no rádio de coelhos
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Data
2004-08-01
Autores
Moraes, Paola Castro [UNESP]
Padilha Filho, João Guilherme [UNESP]
Canola, Júlio Carlos [UNESP]
Santos, Luis Alberto dos
Macoris, Delphin da Graça [UNESP]
Alessi, Antônio Carlos [UNESP]
Castro, Márcio Botelho de
Dória Neto, Francisco de Assis [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Resumo
OBJETIVO: Avaliar a biocompatibilidade do cimento de fosfato de cálcio, para verificar sua eficácia como possível substituto ósseo. MÉTODOS: No presente trabalho, foi utilizado cimento de fosfato de cálcio em rádio de 8 coelhos, separados em dois grupos (GI e GII), referentes aos tempos de observação de 12 e 26 semanas pós-operatórias, a fim de se observar as reações entre este biomaterial e o tecido ósseo do animal. Foram feitas análises radiográficas e de densitometria óptica, além de microscopia óptica e eletrônica de varredura. RESULTADOS: Observou-se, ao final do experimento, que o cimento à base de fosfato de cálcio foi parcialmente reabsorvido durante o tempo de observação de 26 semanas, apresentando biocompatibilidade, com ausência de reações indesejáveis que pudessem ser atribuídas aos implantes. CONCLUSÕES: O cimento à base de fosfato de cálcio foi biocompatível e parcialmente reabsorvido no período de 26 semanas de observação. Tempos maiores de observação são necessários para a avaliação da reabsorção.
PURPOSE: The objective of this paper was to evaluate the biocompatibility of calcium phosphate cement in radius of rabbits. METHODS: For this experiment, calcium phosphate were implanted in the radius of 16 rabbits, divided in two groups (GI and GII), according to postoperative follow-up of 12 and 26 weeks, respectively. Reactions of these biomaterials on animal bone tissue were observed. X-ray, optical densitometry, optical microscopy and scanning electron microscopy analyses were performed. RESULTS: It was observed that calcium phosphate cement were partially resorbed during the 26-week follow-up, showing biocompatibility, with absence of inflammatory or other undesirable reactions due to the implants. CONCLUSIONS: Calcium phosphate-based cements did not cause inflammatory reactions when in contact with the osseous tissue, and were therefore biocompatible. Follow-up periods longer than 26 weeks are necessary to better evaluate the behavior of calcium phosphate-based cement.
PURPOSE: The objective of this paper was to evaluate the biocompatibility of calcium phosphate cement in radius of rabbits. METHODS: For this experiment, calcium phosphate were implanted in the radius of 16 rabbits, divided in two groups (GI and GII), according to postoperative follow-up of 12 and 26 weeks, respectively. Reactions of these biomaterials on animal bone tissue were observed. X-ray, optical densitometry, optical microscopy and scanning electron microscopy analyses were performed. RESULTS: It was observed that calcium phosphate cement were partially resorbed during the 26-week follow-up, showing biocompatibility, with absence of inflammatory or other undesirable reactions due to the implants. CONCLUSIONS: Calcium phosphate-based cements did not cause inflammatory reactions when in contact with the osseous tissue, and were therefore biocompatible. Follow-up periods longer than 26 weeks are necessary to better evaluate the behavior of calcium phosphate-based cement.
Descrição
Palavras-chave
Calcium phosphates, Bone cements, Biocompatible materials, Rabbits, Cimento de fosfato de cálcio, Cimento ósseo, Biomateriais, Coelhos
Como citar
Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, n. 4, p. 351-359, 2004.