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dc.contributor.authorTerreri, Maria Teresa R.A.
dc.contributor.authorBernardo, Wanderley Marques
dc.contributor.authorLen, Claudio Arnaldo
dc.contributor.authorda Silva, Clovis Artur Almeida
dc.contributor.authorde Magalhães, Cristina Medeiros Ribeiro
dc.contributor.authorSacchetti, Silvana B.
dc.contributor.authorFerriani, Virgínia Paes Leme
dc.contributor.authorPiotto, Daniela Gerent Petry
dc.contributor.authorCavalcanti, André de Souza
dc.contributor.authorde Moraes, Ana Júlia Pantoja
dc.contributor.authorSztajnbok, Flavio Roberto
dc.contributor.authorde Oliveira, Sheila Knupp Feitosa
dc.contributor.authorCampos, Lucia Maria Arruda
dc.contributor.authorBandeira, Marcia
dc.contributor.authorSantos, Flávia Patricia Sena Teixeira
dc.contributor.authorMagalhães, Claudia Saad [UNESP]
dc.date.accessioned2018-12-11T17:01:42Z
dc.date.available2018-12-11T17:01:42Z
dc.date.issued2016-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.rbre.2015.09.004
dc.identifier.citationRevista Brasileira de Reumatologia, v. 56, n. 1, p. 52-57, 2016.
dc.identifier.issn1809-4570
dc.identifier.issn0482-5004
dc.identifier.urihttp://hdl.handle.net/11449/172671
dc.description.abstractObjective: To establish guidelines based on scientific evidence for the management of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. Description of the evidence collection method: The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparisonand Outcome), to search in key primary scientific information databases. After defining thepotential studies to support the recommendations, these were graduated considering theirstrength of evidence and grade of recommendation. Results: 806 articles were retrieved and evaluated by title and abstract; from these, 32 articleswere selected to support the recommendations. Recommendations: 1. PFAPA is a diagnosis of exclusion established on clinical grounds, and one must suspect of this problem in children with recurrent and periodic febrile episodes of unknown origin, or with recurrent tonsillitis interspersed with asymptomatic periods, especially in children in good general condition and with preservation of weight and height development. 2. Laboratory findings are nonspecific. Additional tests do not reveal pathognomonic changes. 3. The evidence supporting an indication for surgical treatment (tonsillectomy with or without adenoidectomy), is based on two non-blinded randomized clinical trials with small numbers of patients. 4. The use of prednisone at the onset of fever in patients with PFAPA proved to be an effective strategy. There is still need for more qualified evidence to support its use in patients with PFAPA. 5. Despite promising results obtained in studies with IL-1β inhibitors, such studies are limited to a few case reports.en
dc.format.extent52-57
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Reumatologia
dc.sourceScopus
dc.subjectAphthous stomatitis
dc.subjectAutoinflammatory syndromes
dc.subjectCervical adenitis
dc.subjectChildhood
dc.subjectFever
dc.subjectGuidelines
dc.subjectPharyngitis
dc.subjectSyndrome of periodic fever
dc.titleGuidelines for the management and treatment of periodic fever syndromes: Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndromeen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital da Criança de Brasília José Alencar (HCB)
dc.contributor.institutionIrmandade da Santa Casa de Misericórdia de São Paulo
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionHospital Pequeno Príncipe
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSector of Pediatric Rheumatology Department of Pediatrics Universidade Federal de São Paulo (Unifesp)
dc.description.affiliationCenter for Development of Medical Teaching Medicine School Universidade de São Paulo (USP)
dc.description.affiliationPediatric Rheumatology Unit Children's Institute Medicine School Universidade de São Paulo (USP)
dc.description.affiliationHospital da Criança de Brasília José Alencar (HCB)
dc.description.affiliationIrmandade da Santa Casa de Misericórdia de São Paulo
dc.description.affiliationService of Immunology Allergy and Pediatric Rheumatology Department of Pediatrics Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP)
dc.description.affiliationService of Rheumatology Hospital das Clínicas Universidade Federal de Pernambuco (UFPE)
dc.description.affiliationUniversidade Federal do Pará (UFPA)
dc.description.affiliationService of Rheumatology Nucleus Adolescents' Health Studies Universidade do Estado do Rio de Janeiro (UERJ)
dc.description.affiliationInstituto de Puericultura e Pediatria Martagão Gesteira Service of Pediatric Rheumatology Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliationHospital Pequeno Príncipe
dc.description.affiliationService of Rheumatology Hospital das Clínicas Universidade Federal de Minas Gerais (UFMG)
dc.description.affiliationPediatric Rheumatology Unit Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespPediatric Rheumatology Unit Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp)
dc.identifier.doi10.1016/j.rbre.2015.09.004
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-84960432620
dc.identifier.file2-s2.0-84960432620.pdf
dc.relation.ispartofsjr0,340
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