Show simple item record

dc.contributor.authorFerreira, Paula S. [UNESP]
dc.contributor.authorSpolidorio, Luis C. [UNESP]
dc.contributor.authorManthey, John A.
dc.contributor.authorCesar, Thais B. [UNESP]
dc.date.accessioned2018-12-11T17:03:41Z
dc.date.available2018-12-11T17:03:41Z
dc.date.issued2016-06-01
dc.identifierhttp://dx.doi.org/10.1039/c5fo01541c
dc.identifier.citationFood and Function, v. 7, n. 6, p. 2675-2681, 2016.
dc.identifier.issn2042-650X
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/11449/173113
dc.description.abstractThe flavanones hesperidin, eriocitrin and eriodictyol were investigated for their prevention of the oxidative stress and systemic inflammation caused by high-fat diet in C57BL/6J mice. The mice received a standard diet (9.5% kcal from fat), high-fat diet (45% kcal from fat) or high-fat diet supplemented with hesperidin, eriocitrin or eriodictyol for a period of four weeks. Hesperidin, eriocitrin and eriodictyol increased the serum total antioxidant capacity, and restrained the elevation of interleukin-6 (IL-6), macrophage chemoattractant protein-1 (MCP-1), and C-reactive protein (hs-CRP). In addition, the liver TBARS levels and spleen mass (g per kg body weight) were lower for the flavanone-treated mice than in the unsupplemented mice. Eriocitrin and eriodictyol reduced TBARS levels in the blood serum, and hesperidin and eriodictyol also reduced fat accumulation and liver damage. The results showed that hesperidin, eriocitrin and eriodictyol had protective effects against inflammation and oxidative stress caused by high-fat diet in mice, and may therefore prevent metabolic alterations associated with the development of cardiovascular diseases in other animals.en
dc.format.extent2675-2681
dc.language.isoeng
dc.relation.ispartofFood and Function
dc.sourceScopus
dc.titleCitrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat dieten
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUSDA
dc.description.affiliationFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista Campus Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara-Jau km 1
dc.description.affiliationFaculdade de Odontologia UNESP Univ Estadual Paulista Campus Araraquara Departamento de Fisiologia e Patologia, Humaitá 1680
dc.description.affiliationU.S. Horticultural Research Laboratory Agricultural Research Service USDA, 2001 South Rock Road
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista Campus Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara-Jau km 1
dc.description.affiliationUnespFaculdade de Odontologia UNESP Univ Estadual Paulista Campus Araraquara Departamento de Fisiologia e Patologia, Humaitá 1680
dc.identifier.doi10.1039/c5fo01541c
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84975522802
dc.relation.ispartofsjr1,209
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record