Biopharmaceuticals from microorganisms: from production to purification

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Data

2016-12-01

Autores

Jozala, Angela Faustino
Geraldes, Danilo Costa
Tundisi, Louise Lacalendola
Feitosa, Valker de Araújo
Breyer, Carlos Alexandre [UNESP]
Cardoso, Samuel Leite
Mazzola, Priscila Gava
de Oliveira-Nascimento, Laura
Rangel-Yagui, Carlota de Oliveira
Magalhães, Pérola de Oliveira

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Resumo

The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.

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Palavras-chave

Biopharmaceuticals, Biotechnology, Downstream process, Fermentation process, Upstream process

Como citar

Brazilian Journal of Microbiology, v. 47, p. 51-63.