Biopharmaceuticals from microorganisms: from production to purification
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Data
2016-12-01
Autores
Jozala, Angela Faustino
Geraldes, Danilo Costa
Tundisi, Louise Lacalendola
Feitosa, Valker de Araújo
Breyer, Carlos Alexandre [UNESP]
Cardoso, Samuel Leite
Mazzola, Priscila Gava
de Oliveira-Nascimento, Laura
Rangel-Yagui, Carlota de Oliveira
Magalhães, Pérola de Oliveira
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Editor
Resumo
The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
Descrição
Palavras-chave
Biopharmaceuticals, Biotechnology, Downstream process, Fermentation process, Upstream process
Como citar
Brazilian Journal of Microbiology, v. 47, p. 51-63.