Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

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2017-03-01

Autores

da Rocha, Claudia Quintino [UNESP]
de-Faria, Felipe Meira
Marcourt, Laurence
Ebrahimi, Samad Nejad
Kitano, Bruna Tiemi
Ghilardi, Amanda Franceschini
Luiz Ferreira, Anderson
de Almeida, Ana Cristina Alves
Dunder, Ricardo José
Souza-Brito, Alba Regina Monteiro

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Resumo

The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.

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Arrabidaea brachypoda, Bignoniaceae, Gastric ulcer, Gastroprotective effect, Glycosylated dimeric flavonoids, In vivo assays

Como citar

Phytochemistry, v. 135, p. 93-105.