RSS 1.0Artigos - Farmacologia - IBB
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Use of giant unilamellar lipid vesicles as antioxidant carriers in in vitro culture medium of bovine embryos
Rossi, Luana Teixeira Rodrigues
; Nunes, Giovana Barros ; da Silva, Cíntia Rodrigues ; de Rossi, Hugo ; dos Santos, Priscila Helena ; Nogueira, Marcelo Fábio Gouveia ; Aoki, Pedro Henrique Benites ; Mingoti, Gisele Zoccal (Scientific Reports, 2022) [Artigo]
Giant unilamellar vesicles (GUVs) are composed of lipophilic layers and are sensitive to the action of reactive oxygen species (ROS). The use of GUVs as microcarriers of biological macromolecules is particularly interesting ... -
Analysis of the associations of the T-786C and Glu298Asp polymorphisms of the eNOS gene as risk factors in the rupture of intracranial aneurysms
; ; ; ; Sandrim, Valeria Cristina; ; ; (Meta Gene, 2022) [Artigo]
The mechanisms involved in aneurysmal etiology are complex and only partially understood. Genetic risk factors have already been related to the process of aneurysm rupture. Among the genetic factors, the T-786C and Glu298Asp ... -
Effects of nandrolone decanoate and resistance exercise on skeletal muscle in adult male rats
; Agati, Leandro B.; Pereira, Oduvaldo C.M. (International Journal of Morphology, 2012) [Artigo]
The aim of this study was to compare the effects of resistance exercise associated or not with nandrolone decanoate (ND) on skeletal muscles and body mass of adult male rats. Training protocol consisted of 15 jump sessions, ... -
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats
(Brazilian Journal of Medical and Biological Research, 2020) [Artigo]This study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of ... -
In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence
(Animal Reproduction, 2017) [Artigo]In vitro production (IVP) of bovine embryos has become widespread technology implemented in cattle breeding and production. Here, we review novel data on cumulus/granulosa cell gene expression, as determined by RNAseq on ... -
Treatment with cyclic adenosine monophosphate modulators prior to in vitro maturation alters the lipid composition and transcript profile of bovine cumulus-oocyte complexes and blastocysts
(Reproduction, Fertility and Development, 2018) [Artigo]Mammalian oocytes resume meiosis spontaneously after removal from the ovarian follicle. We tested the effects of a 2-h prematuration treatment (Pre-IVM) with forskolin (FSK) and 3-isobutyl-1-methylxanthine (IBMX) in bovine ... -
Influence of nitric oxide and phosphodiesterases during in vitro maturation of bovine oocytes on meiotic resumption and embryo production
(Zygote, 2017) [Artigo]This study aimed to examine the effects of nitric oxide (NO) and different phosphodiesterase (PDE) families on meiosis resumption, nucleotides levels and embryo production. Experiment I, COCs were matured in vitro with the ... -
Screening of biotechnical parameters for production of bovine inter-subspecies embryonic chimeras by the aggregation of tetraploid Bos indicus and diploid crossbred Bos taurus embryos
(Reproductive Biology, 2016) [Artigo]The aggregation of a tetraploid zebu embryo (Bos indicus, a thermotolerant breed) with a diploid taurine embryo (Bos taurus, a thermosensitive breed) should create a complete taurine fetus, whose extra-embryonic components, ... -
Exercise increases the phenylephrine effects in isolated portal vein of trained rats
(Vascular Pharmacology, 2009) [Artigo]Physical exercise evokes an extensive circulatory redistribution. However, the influence of exercise upon the effects of sympathomimetic agonists in veins was not well studied. Thus, the present study aimed to determine ... -
Pharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens
(Polish Journal of Pharmacology, 2003) [Artigo]We report that the classical guanylate cyclase inhibitor methylene blue (MB, 1 μM or 10 μM), but not the selective guanylate cyclase inhibitor 1H-[1,2,4]oxidazolo[4,3-a]quinoxalin-1-one (1 μM) or nitric oxide synthase ... -
Abortive and/or embryofetotoxic effect of Cinnamomum zeylanicum leaf extracts in pregnant rats
(Fitoterapia, 1994) [Artigo]Female Wistar rats received by gavage 70 mg/kg of aqueous and chloroform extracts of C. zeylanicum during pregnancy. The results showed that the females treated with both the extracts presented an increased number of ... -
Effects of methoxyflurane on intraocular and cerebrospinal fluid pressure in dogs with spontaneous or artificial respiration
(Brazilian Journal of Medical and Biological Research, 1979) [Artigo]Methoxyflurane (0.2 ml/kg over 5 min), administered by inhalation to dogs with spontaneous respiration, resulted approximately 10 minutes later in a significant increase of intraocular pressure (IOP) (13.3 mm Hg), cerebrospinal ... -
Generation of primordial germ cell-like cells from iPSCs derived from turner syndrome patients
; ; ; Botigelli, Ramon Cesar; ; ; ; ; ; (Cells, 2021) [Artigo]
Turner syndrome (TS) is a genetic disorder in females with X Chromosome monosomy associated with highly variable clinical features, including premature primary gonadal failure leading to ovarian dysfunction and infertility. ... -
Desenvolvimento de um método analítico rápido e eficiente para a determinação de corticosteroídes plasmáticos por injeção direta em coluna cromatográfica ISRP-C18 por CLAE
Toledo-Pinto, E. A.; Menezes, M. L. ; Pereira, O. C.M. (Ecletica Quimica, 2010) [Artigo]
The present work had as aim the development of simple an analytical method, fast efficient and the determination of corticosteroids (cortisone, corticosterone, acetate of hidrocortisone and acetate of dexametasone) in ... -
Cattle in vitro induced pluripotent stem cells generated and maintained in 5 or 20% oxygen and different supplementation
; Botigelli, Ramon Cesar; ; ; ; ; ; ; ; de Castro, Raquel Vasconcelos Guimarães et al. (Cells, 2021) [Artigo]
The event of cellular reprogramming into pluripotency is influenced by several factors, such as in vitro culture conditions (e.g., culture medium and oxygen concentration). Herein, bovine iPSCs (biPSCs) were generated in ... -
State-of-the-art of the superstimulatory treatments utilized in bovine embryo transfer protocols and future perspectives for new improvements
Gouveia Nogueira, Marcelo F.; Barros, Ciro Moraes (Animal Reproduction: New Research Developments, 2011) [Capítulo de livro]
In the present article superstimulatory treatments based upon a protocol coined P-36,in which the time of ovulation is controlled by a progesterone source and exogenousadministration of LH, allowing the use of fixed-time ... -
In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues
; ; ; Tibério, Juliana; (Surgical and Cosmetic Dermatology, 2012) [Artigo]
Introduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. ... -
Chronic stress improves the myocardial function without altering l-type ca+2 channel activity in rats
Bruder-Nascimento, Thiago; Campos, Dijon Henrique Salome ; ; ; Okoshi, Katashi ; Cordellini, Sandra ; Cicogna, Antônio Carlos (Arquivos Brasileiros de Cardiologia, 2012) [Artigo]
Background: Chronic stress is associated with cardiac remodeling; however the mechanisms have yet to be clarified. Objective: The purpose of this study was test the hypothesis that chronic stress promotes cardiac dysfunction ... -
Can vitamins C and E restore the androgen level and hypersensitivity of the vas deferens in hyperglycemic rats?
; ; Assumpção, Thaiane A.; Campos, Kleber E. ; Damasceno, Débora C. ; Pereira, Oduvaldo C. M. ; Kempinas, Wilma D. G. (Pharmacological Reports, 2011) [Artigo]
Diabetic neuropathy can affect the male reproductive system. The aim of this study was therefore to evaluate whether antioxidant (vitamins C and/or E) treatment could attenuate reproductive dysfunctions in hyperglycemic ... -
Ejaculatory dysfunction in streptozotocin-induced diabetic rats: The role of testosterone
; ; Piffer, Renata C.; ; Pereira, Oduvaldo C. M. ; Kempinas, Wilma G. (Pharmacological Reports, 2011) [Artigo]
Hyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ...