Now showing items 1-10 of 30
The Development of a Universal In Silico Predictor of Protein-Protein Interactions
(PLOS ONE, 2013-05-31) [Artigo]
Protein-protein interactions (PPIs) are essential for understanding the function of biological systems and have been characterized using a vast array of experimental techniques. These techniques detect only a small proportion ...
A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data
(BMC Genomics, 2010-12-22) [Artigo]
Background: The genome-wide identification of both morbid genes, i.e., those genes whose mutations cause hereditary human diseases, and druggable genes, i.e., genes coding for proteins whose modulation by small molecules ...
Transcriptome response signatures associated with the overexpression of a mitochondrial uncoupling protein (AtUCP1) in tobacco
(Plos One, 2015-06-24) [Artigo]
Mitochondrial inner membrane uncoupling proteins (UCP) dissipate the proton electrochemical gradient established by the respiratory chain, thus affecting the yield of ATP synthesis. UCP overexpression in plants has been ...
Cooperative RNA Polymerase Molecules Behavior on a Stochastic Sequence-Dependent Model for Transcription Elongation
(PLOS ONE, 2013-02-21) [Artigo]
The transcription process is crucial to life and the enzyme RNA polymerase (RNAP) is the major component of the transcription machinery. The development of single-molecule techniques, such as magnetic and optical tweezers, ...
Automatic classification of enzyme family in protein annotation
(Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2009-09-14) [Trabalho apresentado em evento]
Most of the tasks in genome annotation can be at least partially automated. Since this annotation is time-consuming, facilitating some parts of the process - thus freeing the specialist to carry out more valuable tasks - ...
Topography-specific spindle frequency changes in Obstructive Sleep Apnea
(Bmc Neuroscience, 2012-07-31) [Artigo]
Background: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, ...
In silico network topology-based prediction of gene essentiality
(Physica A: Statistical Mechanics and Its Applications, 2008-02-01) [Artigo]
The identification of genes essential for survival is important for the understanding of the minimal requirements for cellular life and for drug design. As experimental studies with the purpose of building a catalog of ...
Sleep Spindle Frequency Modulation (Chirp) in Obstructive Sleep Apnea
(Neurology, 2012-04-01) [Resumo]
The development of an open-access database for human transcriptional regulation interactions
(BMC Bioinformatics, 2011-11-21) [Resumo]
Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology
(PLOS ONE, 2013-10-25) [Artigo]
Cancer has been increasingly recognized as a systems biology disease since many investigators have demonstrated that this malignant phenotype emerges from abnormal protein-protein, regulatory and metabolic interactions ...