Now showing items 1-5 of 5
Exploring the multifactorial nature of autism through computational systems biology: Calcium and the Rho GTPase RAC1 under the spotlight
(NeuroMolecular Medicine, 2013-06-01) [Resenha]
Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication accompanied with repetitive behavioral patterns and unusual stereotyped interests. Autism is considered a highly ...
Snake venom phospholipase A(2) inhibitors: Medicinal chemistry and therapeutic potential
(Current Topics In Medicinal Chemistry, 2007-01-01) [Resenha]
Phospholipases A(2) (PLA(2)s) are commonly found in snake venoms from Viperidae, Hydrophidae and Elaphidae families and have been extensively studied due to their pharmacological and physiopathological effects in living ...
Phospholipase A(2) myotoxins from Bothrops snake venoms: Structure-function relationship
(Current Organic Chemistry, 2004-11-01) [Resenha]
Phospholipases A(2) constitute the major components from Bothrops snake venoms and have been extensively investigated not only because they are relatively very abundant in these venoms but mainly because they display a ...
Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review
(Frontiers In Physiology, 2016-03-08) [Resenha]
Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification of essential genes is very ...
Structural Biology and Regulation of Protein Import into the Nucleus
(Journal Of Molecular Biology, 2016-05-22) [Resenha]
Proteins are translated in the cytoplasm, but many need to access the nucleus to perform their functions. Understanding how these nuclear proteins are transported through the nuclear envelope and how the import processes ...