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dc.contributor.authorMastroianni, Patrícia de Carvalho [UNESP]
dc.contributor.authorForgerini, Marcela [UNESP]
dc.date.accessioned2018-12-11T17:18:33Z
dc.date.available2018-12-11T17:18:33Z
dc.date.issued2018-01-01
dc.identifierhttp://dx.doi.org/10.1590/1980-57642018dn12-010015
dc.identifier.citationDementia e Neuropsychologia, v. 12, n. 1, p. 97-100, 2018.
dc.identifier.issn1980-5764
dc.identifier.urihttp://hdl.handle.net/11449/176011
dc.description.abstractAn elderly patient, aged 76 years, diagnosed with dysphagia, depression, hypothyroidism, Alzheimer’s disease and mild cognitive deficit, was identified with sertraline and levothyroxine- drug-related problems. Medication Therapy Management (MTM) was used to adjust therapy to the patient’s needs by macerating sertraline tablets and solubilizing them in 10-30 mL of orange juice. The patient was advised to take levothyroxine after fasting. Six months later, pharmaceutical follow-up identified an increase in the Mini-Mental State Exam score from 22 to 26 and a decrease in the Clinical Dementia Rating (CDR) scale score from 1.0 to 0.5 in conjunction with mood and physical improvements, as well as a significant decrease in aggressiveness and agitation. Cognitive deficit may be a result of poor drug administration procedures, leading to drug ineffectiveness. Optimizing levothyroxine and sertraline administration, based on knowledge of their physicochemical properties, improves their clinical effectiveness, including the cognition of patients with Alzheimer’s disease and dysphagia.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent97-100
dc.language.isoeng
dc.relation.ispartofDementia e Neuropsychologia
dc.sourceScopus
dc.subjectCognitive dysfunction
dc.subjectDeglutition disorder
dc.subjectMedication errors
dc.subjectMedication therapy management
dc.subjectPharmaceutical care
dc.subjectSertraline
dc.titleAjustes da administração de medicamentos para pacientes idosos com disfagia: Um relato de casopt
dc.title.alternativeDrug administration adjustments for elderly patients with dysphagia: A case reporten
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.identifier.doi10.1590/1980-57642018dn12-010015
dc.identifier.scieloS1980-57642018000100097
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2014/00312-5
dc.description.sponsorshipIdCNPq: 459461/2014-1
dc.identifier.scopus2-s2.0-85043773073
dc.identifier.fileS1980-57642018000100097.pdf
dc.identifier.lattes4160558780902988
dc.identifier.orcid0000-0001-8467-7278
unesp.author.lattes4160558780902988[1]
unesp.author.orcid0000-0001-8467-7278[1]
dc.relation.ispartofsjr0,205
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