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dc.contributor.authorScarim, Cauê Benito [UNESP]
dc.contributor.authorChiba, Diego Eidy [UNESP]
dc.contributor.authorChelucci, Rafael Consolin [UNESP]
dc.contributor.authordos Santos, Jean Leandro [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.date.accessioned2018-12-11T17:18:39Z
dc.date.available2018-12-11T17:18:39Z
dc.date.issued2017-01-01
dc.identifier.citationChagas Disease: Prevalence, Diagnosis and Treatment Options, p. 85-116.
dc.identifier.urihttp://hdl.handle.net/11449/176037
dc.description.abstractOptimal pharmacotherapy occurs when we have selectivity and no toxicity. The discovery of specific pathways or enzymes that are vital forcell or parasite survival is also vital for the design of new specific, non-toxic drugs for the treatment of cancer, microbial or parasitic diseases. This chapter describes the main validated therapeutic targets in the research of new drugs for the treatment of Chagas' disease, such as cysteine proteases, ergosterol metabolic pathways, thiol-dependent mechanisms (trypanothione reductase), glycolytic pathways, transsialidase enzymes, the transport and metabolism of polyamines, among others, as well as examples from the scientific literature. This also includes what is already in clinical trials that involves the specified targets.en
dc.format.extent85-116
dc.language.isoeng
dc.relation.ispartofChagas Disease: Prevalence, Diagnosis and Treatment Options
dc.sourceScopus
dc.subjectChagas' disease
dc.subjectMolecular targets
dc.subjectT. cruzi
dc.subjectTherapeutic targets
dc.titleTherapeutic targets in chagas diseaseen
dc.typeCapítulo de livro
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho UNESP
dc.description.affiliationUnespDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista Júlio de Mesquita Filho UNESP
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-85044219610
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