Therapeutic targets in chagas disease
Nenhuma Miniatura disponível
Data
2017-01-01
Autores
Scarim, Cauê Benito [UNESP]
Chiba, Diego Eidy [UNESP]
Chelucci, Rafael Consolin [UNESP]
dos Santos, Jean Leandro [UNESP]
Chin, Chung Man [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Optimal pharmacotherapy occurs when we have selectivity and no toxicity. The discovery of specific pathways or enzymes that are vital forcell or parasite survival is also vital for the design of new specific, non-toxic drugs for the treatment of cancer, microbial or parasitic diseases. This chapter describes the main validated therapeutic targets in the research of new drugs for the treatment of Chagas' disease, such as cysteine proteases, ergosterol metabolic pathways, thiol-dependent mechanisms (trypanothione reductase), glycolytic pathways, transsialidase enzymes, the transport and metabolism of polyamines, among others, as well as examples from the scientific literature. This also includes what is already in clinical trials that involves the specified targets.
Descrição
Palavras-chave
Chagas' disease, Molecular targets, T. cruzi, Therapeutic targets
Como citar
Chagas Disease: Prevalence, Diagnosis and Treatment Options, p. 85-116.