Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
Data
2018-02-01
Autores
Urbano, Ana Paula Signori [UNESP]
Sassaki, Ligia Yukie [UNESP]
De Souza Dorna, Mariana [UNESP]
Presti, Paula Torres [UNESP]
De Barros Leite Carvalhaes, Maria Antonieta [UNESP]
Martini, Ligia Araújo
Ferreira, Ana Lucia Anjos [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.
Descrição
Palavras-chave
Biomarkers, Body composition, C-reactive protein, Severity of illness index, Ulcerative colitis
Como citar
Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018.