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Tratamento de granulomas laríngeos pós-intubação: revisão sistemática e meta-análise proporcional

dc.contributor.authorRimoli, Caroline Fernandes [UNESP]
dc.contributor.authorMartins, Regina Helena Garcia [UNESP]
dc.contributor.authorCatâneo, Daniele Cristina [UNESP]
dc.contributor.authorImamura, Rui
dc.contributor.authorCatâneo, Antonio José Maria [UNESP]
dc.date.accessioned2018-12-11T17:19:46Z
dc.date.available2018-12-11T17:19:46Z
dc.date.issued2018-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.bjorl.2018.03.003
dc.identifier.citationBrazilian Journal of Otorhinolaryngology.
dc.identifier.issn1808-8686
dc.identifier.issn1808-8694
dc.identifier.urihttp://hdl.handle.net/11449/176245
dc.description.abstractIntroduction: Laryngeal granulomas post intubation are benign but recurrent lesions. There is no consensus for its treatment. Objective: To describe the effectiveness of different treatment modalities for primary or recurrent laryngeal granulomas resulting from endotracheal intubation. Methods: Systematic review and proportional meta-analysis. Eligibility criteria – experimental or observational studies with at least five subjects. Outcomes studied – granuloma resolution, recurrence, and time for resolution. Databases used – Pubmed, Embase, Lilacs, and Cochrane. The Stats Direct 3.0.121 program was used. Results: Six studies were selected, with 85 patients. The treatments registered were: antireflux therapy, speech therapy, anti-inflammatory drugs, steroids, antibiotics, zinc sulfate and surgery. 85 patients from six studies had primary treatment: surgery ± associations (41 patients), resolution chance 75% (95% CI: 0.3–100%, I2 = 90%), absolute relapse risk 25% (95% CI: 0.2–71%); medical treatment (44 patients), resolution chance 86% (95% CI: 67–97%); and absolute relapse risk 14% (95% CI: 3–33%). There was no significant difference between groups. Three studies, encompassing 19 patients, analyzed secondary treatment (failure or recurrence after primary treatment); three subjects presented new recurrence. The time needed to resolve the lesions varied from immediate, after surgery, to 23 months, for inhaled steroid. Conclusion: There is no evidence of high quality that proves the efficacy of any treatment for laryngeal granulomas resulting from endotracheal intubation.en
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.sourceScopus
dc.subjectGranulomas
dc.subjectLarynx
dc.subjectSystematic review
dc.subjectTreatment
dc.titleTreatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysisen
dc.titleTratamento de granulomas laríngeos pós-intubação: revisão sistemática e meta-análise proporcionalpt
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Medicina de Botucatu Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Medicina de Botucatu Departamento de Cirurgia
dc.description.affiliationUniversidade de São Paulo (USP) Departamento de Otorrinolaringologia
dc.description.affiliationUnespUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Medicina de Botucatu Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUnespUniversidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Medicina de Botucatu Departamento de Cirurgia
dc.identifier.doi10.1016/j.bjorl.2018.03.003
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85046139677
dc.identifier.file2-s2.0-85046139677.pdf
unesp.author.lattes1919165905574226[5]
unesp.author.orcid0000-0003-2330-9337[5]
dc.relation.ispartofsjr0,443
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