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dc.contributor.authorBatista-Duharte, Alexander [UNESP]
dc.contributor.authorTéllez-Martínez, Damiana [UNESP]
dc.contributor.authorRoberto de Andrade, Cleverton [UNESP]
dc.contributor.authorPortuondo, Deivys Leandro [UNESP]
dc.contributor.authorJellmayer, Juliana Aparecida [UNESP]
dc.contributor.authorPolesi, Marisa Campos [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.date.accessioned2018-12-11T17:22:49Z
dc.date.available2018-12-11T17:22:49Z
dc.date.issued2018-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.funbio.2018.08.004
dc.identifier.citationFungal Biology.
dc.identifier.issn1878-6146
dc.identifier.urihttp://hdl.handle.net/11449/176860
dc.description.abstractLittle is known about the differences in the CD4+ T-cell response induced by Sporothrix schenckii and Sporothrix brasiliensis, the most virulent species that cause sporotrichosis. Here, the helper (Th) and regulatory T cells (Tregs) responses were evaluated comparatively in a murine model of sporotrichosis on days 7, 21 and 35 after subcutaneous infection with either S. schenckii or S. brasiliensis conidia. The fungal load was measured at the site of infection, as well as in the liver and spleen. The Th1/Th17/Tregs responses were analyzed in the spleen, while the level of IL-2, IL-4, IL-6, TNF-alpha, IFN-ɣ, IL-17A and IL-10 cytokines were measured at the local site of infection on 24 h postinfections and in sera on the indicated days. S. brasiliensis caused a longer-lasting infection in the skin and chronic systemic dissemination associated to more severe granulomatous lesions. Similar Th1/Th1-Th17/Tregs responses were induced by both S. brasiliensis and S. schenckii on 7th and 21st d.p.i but on 35 d.p.i a reduction of Th1 and Th1-Th17 cells, associated to higher values of Th17/Tregs cells was observed only in S. brasiliensis-infected mice. In summary, S. brasiliensis caused a more severe disease associated with sustained Th17/Tregs responses than S. schenckii in mice.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.isoeng
dc.relation.ispartofFungal Biology
dc.sourceScopus
dc.subjectCytokines
dc.subjectSporotrichosis
dc.subjectT helper cells
dc.subjectTregs
dc.subjectVirulence
dc.titleSporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in miceen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Clinical Analysis
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Department of Physiology & Pathology
dc.description.affiliationLaboratório de Imunología Clínica Dpto Analises Clinicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) Rod, Araraquara-Jaú – Km 1, Campus Ville
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Clinical Analysis
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Department of Physiology & Pathology
dc.description.affiliationUnespLaboratório de Imunología Clínica Dpto Analises Clinicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) Rod, Araraquara-Jaú – Km 1, Campus Ville
dc.identifier.doi10.1016/j.funbio.2018.08.004
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85053615528
dc.identifier.file2-s2.0-85053615528.pdf
unesp.author.orcid0000-0002-1875-0518[1]
dc.relation.ispartofsjr1,134
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