Show simple item record

dc.contributor.authorPereira, Camila Scacco [UNESP]
dc.contributor.authorStringhetta-Garcia, Camila Tami [UNESP]
dc.contributor.authorda Silva Xavier, Lilian [UNESP]
dc.contributor.authorTirapeli, Keny Gonçalves [UNESP]
dc.contributor.authorPereira, Ariana Aparecida Ferreira [UNESP]
dc.contributor.authorKayahara, GiselIi Mitsuy [UNESP]
dc.contributor.authorTramarim, José Marcelo [UNESP]
dc.contributor.authorCrivelini, Marcelo Macedo [UNESP]
dc.contributor.authorPadovani, Karina Stringhetta
dc.contributor.authorLeopoldino, Andréia Machado
dc.contributor.authorLouzada, Mário Jefferson Quirino [UNESP]
dc.contributor.authorBelló-Klein, Adriane
dc.contributor.authorLlesuy, Susana Francisca
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.authorChaves-Neto, Antonio Hernandes [UNESP]
dc.contributor.authorNakamune, Ana Cláudia de Melo Stevanato [UNESP]
dc.date.accessioned2018-12-11T17:23:34Z
dc.date.available2018-12-11T17:23:34Z
dc.date.issued2017-11-01
dc.identifierhttp://dx.doi.org/10.1016/j.exger.2017.07.006
dc.identifier.citationExperimental Gerontology, v. 98, p. 148-152.
dc.identifier.issn1873-6815
dc.identifier.issn0531-5565
dc.identifier.urihttp://hdl.handle.net/11449/177035
dc.description.abstractDuring perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent148-152
dc.language.isoeng
dc.relation.ispartofExperimental Gerontology
dc.sourceScopus
dc.subjectBone
dc.subjectIlex paraguariensis
dc.subjectOxidative stress
dc.subjectPerimenopause
dc.titlellex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopauseen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFederal University of Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversity of Buenos Aires
dc.description.affiliationPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas-SBFis São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Pathology and Clinical Propaedeutics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Clinical Toxicological and Bromatological Analysis Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationDepartment of Support Animal Production and Health São Paulo State University (Unesp) Veterinary Medicine School
dc.description.affiliationDepartment of Physiology Health Basic Sciences Institute Federal University of Rio Grande do Sul (UFRGS)
dc.description.affiliationDepartment of Analytical Chemistry and Physical Chemistry -School of Pharmacy and Biochemistry University of Buenos Aires
dc.description.affiliationDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicas-SBFis São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Pathology and Clinical Propaedeutics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Support Animal Production and Health São Paulo State University (Unesp) Veterinary Medicine School
dc.description.affiliationUnespDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.identifier.doi10.1016/j.exger.2017.07.006
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85028070046
dc.identifier.file2-s2.0-85028070046.pdf
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
unesp.author.lattes4408095517346846[4]
unesp.author.orcid0000-0003-3661-8016[5]
unesp.author.orcid0000-0001-5098-8406 0000-0001-5098-8406[17]
unesp.author.orcid0000-0003-4859-0583[4]
dc.relation.ispartofsjr1,450
Localize o texto completo

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record