Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão

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Data

2015-01-01

Autores

Mostachio, Giuliano Queiroz
Apparício, Maricy [UNESP]
Motheo, Tathiana Ferguson [UNESP]
Alves, Aracélle Elisane
Vicente, Wilter Ricardo Russiano [UNESP]

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Resumo

The pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was investigated and has shown to induce atrophy of the gland. Based on that, the aims of this study were to compare the effects of administration of BT-A with orchiectomy in the treatment of BPH, in addition to assessing the effects of BT-A on libido and semen quality. Therefore, 16 sexually intact male dogs were submitted to orchiectomy or administration of 500U BT-A, and evaluated for 16 weeks. Orchiectomy presented excellent results, reducing the prostate volume up to 80%. Administration of BT-A did not interfered on libido, erection or semen characteristics. On the other hand, reduced significantly the prostate volume. The results suggest that intraprostatic injection of BT-A is an effective alternative treatment without adverse effects for valuable breeding dogs with BPH. However, this therapy showed lower reduction of prostate volume when compared to orchiectomy.

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Palavras-chave

BPH, Dog, Neurotoxin, Orchiectomy, Prostate, Semen

Como citar

Ciencia Rural, v. 45, n. 9, p. 1654-1659, 2015.