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dc.contributor.authorPiacenti-Silva, Marina [UNESP]
dc.contributor.authorMatos, Adriana Arruda
dc.contributor.authorPaulin, João Vitor [UNESP]
dc.contributor.authorAlavarce, Rafaela Alves da Silva
dc.contributor.authorde Oliveira, Rodrigo Cardoso
dc.contributor.authorGraeff, Carlos FO [UNESP]
dc.date.accessioned2018-12-11T17:29:06Z
dc.date.available2018-12-11T17:29:06Z
dc.date.issued2016-11-01
dc.identifierhttp://dx.doi.org/10.1002/pi.5192
dc.identifier.citationPolymer International, v. 65, n. 11, p. 1347-1354, 2016.
dc.identifier.issn1097-0126
dc.identifier.issn0959-8103
dc.identifier.urihttp://hdl.handle.net/11449/178161
dc.description.abstractBiocompatibility tests were performed for melanin synthesized in water (W-Mel) and dimethylsulfoxide (D-Mel) aiming to evaluate its potential for bioelectronics application. In vitro biocompatibility of melanin was assessed using crystal violet assays with fibroblast cells (NIH3T3) cultured with W-Mel and D-Mel extracts in various dilutions. The results show that a high concentration of melanin kills the cells. However, after periods of 48 h incubation, cell viability is significantly favored after treatment with D-Mel at low concentrations (1:16, 1:32 and 1:64), as opposed to treatment with W-Mel extracts. Cellular adhesion tests show that fibroblast cells adhere to melanin thin films. These results show that D-Mel may be an interesting material for application in bioelectronic devices targeted for implants. © 2016 Society of Chemical Industry.en
dc.format.extent1347-1354
dc.language.isoeng
dc.relation.ispartofPolymer International
dc.sourceScopus
dc.subjectbiocompatibility
dc.subjectbioelectronics
dc.subjectmelanin
dc.subjectpolymer
dc.titleBiocompatibility investigations of synthetic melanin and melanin analogue for application in bioelectronicsen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationDF-FC UNESP – Universidade Estadual Paulista, Av. Eng. Luiz Edmundo Carrijo Coube 14-01
dc.description.affiliationUSP Campus Bauru – Universidade de São Paulo, Alameda Dr Octávio Pinheiro Brisolla 9-75
dc.description.affiliationUNESP – Universidade Estadual Paulista POSMAT – Programa de Pós-Graduação em Ciência e Tecnologia de Materiais, Av. Eng. Luiz Edmundo Carrijo Coube 14-01
dc.description.affiliationUnespDF-FC UNESP – Universidade Estadual Paulista, Av. Eng. Luiz Edmundo Carrijo Coube 14-01
dc.description.affiliationUnespUNESP – Universidade Estadual Paulista POSMAT – Programa de Pós-Graduação em Ciência e Tecnologia de Materiais, Av. Eng. Luiz Edmundo Carrijo Coube 14-01
dc.identifier.doi10.1002/pi.5192
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84978951840
unesp.author.lattes5268607684223281[6]
unesp.author.orcid0000-0003-0162-8273[6]
dc.relation.ispartofsjr0,680
dc.relation.ispartofsjr0,680
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