Epigenetic regulatory mechanisms induced by resveratrol
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Data
2017-11-01
Autores
Fernandes, Guilherme Felipe Santos [UNESP]
Silva, Gabriel Dalio Bernardes [UNESP]
Pavan, Aline Renata [UNESP]
Chiba, Diego Eidy [UNESP]
Chin, Chung Man [UNESP]
Dos Santos, Jean Leandro [UNESP]
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Resumo
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
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Palavras-chave
DNA methyltransferase, Epigenetic targets, Histone acetyltransferase, Histone deacetylase, Resveratrol, SIRT1
Como citar
Nutrients, v. 9, n. 11, 2017.