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dc.contributor.authorOkada, Mieko
dc.contributor.authorFalcão, Luiz Fernando Reis
dc.contributor.authorFerez, David
dc.contributor.authorMartins, José Luiz
dc.contributor.authorErrante, Paolo Ruggero
dc.contributor.authorRodrigues, Francisco Sandro Menezes
dc.contributor.authorCaricati-Neto, Afonso
dc.contributor.authorMarinho, Márcia [UNESP]
dc.contributor.authorFenelon, Guilherme
dc.contributor.authorSouza Oliveira-Júnior, Itamar
dc.date.accessioned2018-12-11T17:35:09Z
dc.date.available2018-12-11T17:35:09Z
dc.date.issued2017-11-01
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170110000008
dc.identifier.citationActa Cirurgica Brasileira, v. 32, n. 11, p. 964-972, 2017.
dc.identifier.issn1678-2674
dc.identifier.issn0102-8650
dc.identifier.urihttp://hdl.handle.net/11449/179431
dc.description.abstractPurpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+I+AT+R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p=0.001) in the heart tissue. The tumor necrosis factoralpha level in plasma decrease in the treated groups when compared with SS+IR group (p=0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.en
dc.format.extent964-972
dc.language.isoeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.sourceScopus
dc.subjectAdrenergic antagonists
dc.subjectAtenolol
dc.subjectCytokines
dc.subjectIschemia
dc.subjectOxidative stress
dc.subjectRats
dc.subjectReperfusion
dc.titleEffect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusionen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationTranslational Medicine Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationDivision of Anesthesia Pain and Intensive Medicine Department of Surgery UNIFESP
dc.description.affiliationUNIFESP
dc.description.affiliationDepartment of Pharmacology UNIFESP
dc.description.affiliationVeterinary Medicine School UNESP
dc.description.affiliationDivision of Cardiology Department of Surgery UNIFESP
dc.description.affiliationDivision of Anesthesia Pain and Intensive Medicine Department of Surgery and Translational Medicine UNIFESP
dc.description.affiliationUnespVeterinary Medicine School UNESP
dc.identifier.doi10.1590/s0102-865020170110000008
dc.identifier.scieloS0102-86502017001100964
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85037850881
dc.identifier.fileS0102-86502017001100964.pdf
dc.relation.ispartofsjr0,395
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