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Perfis cardíaco, metabólico e molecular de ratos sedentários no momento inicial da obesidade

dc.contributor.authorJacobsen, Bruno Barcellos
dc.contributor.authorLeopoldo, Ana Paula Lima
dc.contributor.authorCordeiro, Jóctan Pimentel
dc.contributor.authorde Campos, Dijon Henrique Salomé [UNESP]
dc.contributor.authordo Nascimento, André Ferreira
dc.contributor.authorSugizaki, Mário Mateus
dc.contributor.authorCicogna, Antônio Carlos [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorLeopoldo, André Soares
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 109, n. 5, p. 432-439, 2017.
dc.description.abstractBackground: Different types of high-fat and/or high-energy diets have been used to induce obesity in rodents. However, few studies have reported on the effects observed at the initial stage of obesity induced by high-fat feeding on cardiac functional and structural remodelling.Objective: To characterize the initial moment of obesity and investigate both metabolic and cardiac parameters. In addition, the role of Ca2+ handling in short-term exposure to obesity was verified.Methods: Thirty-day-old male Wistar rats were randomized into two groups (n = 19 each): control (C; standard diet) and high-fat diet (HF, unsaturated high-fat diet). The initial moment of obesity was defined by weekly measurement of body weight (BW) complemented by adiposity index (AI). Cardiac remodelling was assessed by morphological, histological, echocardiographic and papillary muscle analysis. Ca2+ handling proteins were determined by Western Blot.Results: The initial moment of obesity occurred at the 3rd week. Compared with C rats, the HF rats had higher final BW (4%), body fat (20%), AI (14.5%), insulin levels (39.7%), leptin (62.4%) and low-density lipoprotein cholesterol (15.5%) but did not exhibit alterations in systolic blood pressure. Echocardiographic evaluation did not show alterations in cardiac parameters. In the HF group, muscles were observed to increase their +dT/dt (C: 52.6 ± 9.0 g/mm2/s and HF: 68.0 ± 17.0 g/mm2/s; p < 0.05). In addition, there was no changes in the cardiac expression of Ca2+ handling proteins.Conclusion: The initial moment of obesity promotes alterations to hormonal and lipid profiles without cardiac damage or changes in Ca2+ handling.en
dc.description.sponsorshipFundação Estadual de Amparo à Pesquisa do Estado do Espírito Santo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.subjectCardiac function
dc.titleCardiac, metabolic and molecular profiles of sedentary rats in the initial moment of obesityen
dc.titlePerfis cardíaco, metabólico e molecular de ratos sedentários no momento inicial da obesidadept
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.description.affiliationUniversidade Federal do Espírito Santo (UFES)
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina UNESP
dc.description.affiliationUniversidade Federal de Mato Grosso (UFMT)
dc.description.affiliationUnespDepartamento de Clínica Médica Faculdade de Medicina UNESP
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