Physical exercise, IGF-1 and cognition: A systematic review of experimental studies in the elderly
Exercício físico, IGF-1 e cognição: Uma revisão sistemática de estudos experimentais em idosos
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One of hypothetical mechanisms related to cognition is exercise-induced IGF-1. Objective: The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in the elderly. Methods: The article searches were conducted on Pubmed, Web of Science, PsycINFO and Scielo databases and reviewed according to PRISMA guidelines. The inclusion criteria were:  original articles published up to 2017;  samples including elderly;  protocols including physical exercise;  longitudinal studies having exercise as main outcome;  assessment of IGF-1;  cognition assessment. Results: Seven studies were included in this review. Three of the studies showed an exercise-induced increase in IGF-1; three found stable IGF-1 levels and one found a reduction in IGF-1; with and without improvement in cognition. Conclusion: Disparities in the type of physical exercise, protocols and samples under different conditions hinder the establishment of a consensus on IGF-1, cognition and physical exercise.
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