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dc.contributor.authorBraz, Camila Urbano [UNESP]
dc.contributor.authorTaylor, Jeremy Francis
dc.contributor.authorDecker, Jared Egan
dc.contributor.authorBresolin, Tiago [UNESP]
dc.contributor.authorEspigolan, Rafael [UNESP]
dc.contributor.authorGarcia, Diogo Anastácio [UNESP]
dc.contributor.authorGordo, Daniel Gustavo Mansan [UNESP]
dc.contributor.authorMagalhães, Ana Fabrícia Braga [UNESP]
dc.contributor.authorde Albuquerque, Lucia Galvão [UNESP]
dc.contributor.authorde Oliveira, Henrique Nunes [UNESP]
dc.date.accessioned2018-12-11T17:38:08Z
dc.date.available2018-12-11T17:38:08Z
dc.date.issued2018-12-01
dc.identifierhttp://dx.doi.org/10.1016/j.mgene.2018.08.002
dc.identifier.citationMeta Gene, v. 18, p. 73-78.
dc.identifier.issn2214-5400
dc.identifier.urihttp://hdl.handle.net/11449/180098
dc.description.abstractThe aims of this study were to identify haplotyped loci associated with meat tenderness (WBSF) in candidate genes and to search for new polymorphisms in these regions that influence such trait in Nelore cattle. Fifty-two genes that had previously been associated with WBSF or that have biological functions that may influence tenderness were chosen for the haplotype association analysis in 1657 animals. Of the 52 tested candidate genes, two haplotyped loci located in ASAP1 and CAPN1 were significantly associated with WBSF. The effect of the significant haplotype alleles varied from −0.44 to 0.80 and −1.03 to 1.52 kg in CAPN1 and ASAP1, respectively. Exonic regions near and within these loci were chosen for sequencing to search for new polymorphisms. Four SNPs were identified in ASAP1 and seventeen in CAPN1. All SNPs detected in the sequenced regions in ASAP1 showed no association with WBSF even though two of them (rs714391435 and rs109256712) were in strong linkage disequilibrium (LD) with most SNPs that composed the significant haplotyped locus. Four SNPs located in CAPN1 were found for the first time in this study. One of them (rs1121961662) showed significant association with WBSF and is also in strong LD with all SNPs within the significant haplotyped locus in CAPN1 gene. The SNP rs1121961662 could be used as a molecular marker for this QTL and may be included in low-density arrays to improve the selection of meat tenderness in Bos indicus animals.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent73-78
dc.language.isoeng
dc.relation.ispartofMeta Gene
dc.sourceScopus
dc.subjectASAP1
dc.subjectCandidate gene
dc.subjectCAPN1
dc.subjectHaplotype
dc.subjectPolymorphism
dc.subjectWBSF
dc.titlePolymorphism analysis in genes associated with meat tenderness in Nelore cattleen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Missouri
dc.description.affiliationAnimal Science Department São Paulo State University (UNESP) School of Agricultural and Veterinarian Science
dc.description.affiliationDivision of Animal Sciences University of Missouri
dc.description.affiliationUnespAnimal Science Department São Paulo State University (UNESP) School of Agricultural and Veterinarian Science
dc.identifier.doi10.1016/j.mgene.2018.08.002
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdCNPq: 2009/16118-5
dc.description.sponsorshipIdFAPESP: 2013/00035-9
dc.description.sponsorshipIdFAPESP: 2014/23013-3
dc.description.sponsorshipIdCNPq: 480369/2009-7
dc.identifier.scopus2-s2.0-85051383923
dc.identifier.file2-s2.0-85051383923.pdf
unesp.author.orcid0000-0002-5474-1010[1]
unesp.author.orcid0000-0002-3181-1223[10]
dc.relation.ispartofsjr0,598
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