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dc.contributor.authorLeite, Gabriel Adan Araujo [UNESP]
dc.contributor.authorFigueiredo, Thamiris Moreira [UNESP]
dc.contributor.authorPacheco, Tainá Louise [UNESP]
dc.contributor.authorGuerra, Marina Trevizan [UNESP]
dc.contributor.authorAnselmo-Franci, Janete Aparecida
dc.contributor.authorKempinas, Wilma De Grava [UNESP]
dc.date.accessioned2018-12-11T17:38:14Z
dc.date.available2018-12-11T17:38:14Z
dc.date.issued2018-09-02
dc.identifierhttp://dx.doi.org/10.1080/15287394.2018.1504702
dc.identifier.citationJournal of Toxicology and Environmental Health - Part A: Current Issues, v. 81, n. 17, p. 873-892, 2018.
dc.identifier.issn1087-2620
dc.identifier.issn1528-7394
dc.identifier.urihttp://hdl.handle.net/11449/180119
dc.description.abstractDyslipidemias are occurring earlier in different countries due to the increase of obesity, bad eating habits, and sedentary lifestyle. Rosuvastatin reduces serum cholesterol; however, several studies associated statin exposure with male reproduction impairment. Ascorbic acid (AA) is an antioxidant substance that plays a protective role in the male reproductive system. Male rats were randomly divided into 6 experimental groups (n = 10), which received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of AA or 3 or 10 mg/kg/day of rosuvastatin associated with 150 mg/day of AA from post-natal day (PND) 23 until PND 53. On PND 100, males were mated with non-treated female rats to obtain the female pups. The day of vaginal opening and the first estrus were assessed in the offspring. Two sets of females were euthanized on the first estrus after PND 42 and PND 75 to evaluate the histology of reproductive organs and hormone levels. A third set was used for sexual behavior and fertility test around PND 75. Female offspring from males exposed or co-exposed to the higher dose of statin exhibited a lower number of corpora lutea during puberty. On sexual maturity, the experimental group from males that were exposed to 3 mg displayed lower uterine luminal epithelium area. Paternal exposure to rosuvastatin at pre-puberty diminished uterine luminal epithelium in female offspring suggesting epigenetic changes were initiated by statin. Ascorbic acid co-administered to pre-pubertal males was able to ameliorate the reproductive damage in rat female offspring in adulthood.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent873-892
dc.language.isoeng
dc.relation.ispartofJournal of Toxicology and Environmental Health - Part A: Current Issues
dc.sourceScopus
dc.subjectfemale offspring
dc.subjectreproduction
dc.subjectrosuvastatin
dc.subjecttoxicology
dc.subjectVitamin C
dc.titleReproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-pubertyen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationGraduate Program in Cell and Structural Biology Institute of Biology State University of Campinas–UNICAMP
dc.description.affiliationDepartment of Morphology São Paulo State University (Unesp) Institute of Biosciences
dc.description.affiliationDepartment of Morphology Physiology and Basic Pathology School of Dentistry of Ribeirão Preto USP–University of São Paulo
dc.description.affiliationUnespDepartment of Morphology São Paulo State University (Unesp) Institute of Biosciences
dc.identifier.doi10.1080/15287394.2018.1504702
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: #014/13659-3
dc.description.sponsorshipIdCNPq: 308842/2013-8
dc.identifier.scopus2-s2.0-85052010722
dc.identifier.file2-s2.0-85052010722.pdf
unesp.author.orcid0000-0002-9437-6310[1]
dc.relation.ispartofsjr0,888
dc.relation.ispartofsjr0,888
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