Now showing items 1-10 of 76
BCG and BCG/DNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis
(Clinical & Developmental Immunology, 2013-01-01) [Artigo]
A prime-boost strategy conserving BCG is considered the most promising vaccine to control tuberculosis. A boost with a DNA vaccine containing the mycobacterial gene of a heat shock protein (pVAXhsp65) after BCG priming ...
Effect of a polysaccharidic fraction of Agaricus blazei on colorectal carcinogenesis in rats with ulcerative colitis
(Annual Review of Biomedical Sciences, 2005) [Artigo]
First genome sequence of St. Louis encephalitis virus (SLEV) isolated from a human in Brazil
(Archives Of Virology, 2015-05-01) [Artigo]
St. Louis encephalitis virus (SLEV), a member of the family Flaviviridae, genus Flavivirus, is a causative agent of encephalitis in the Americas. In Brazil, sporadic cases of SLEV infection have been reported since 1953, ...
Immunization with pVAXhsp65 Decreases Inflammation and Modulates Immune Response in Experimental Encephalomyelitis
(Neuroimmunomodulation, 2010-01-01) [Artigo]
Background: A DNA vaccine (pVAXhsp65) containing the gene of a heat-shock protein (hsp65) from Mycobacterium leprae showed high immunogenicity and protective efficacy against tuberculosis in BALB/c mice. A possible deleterious ...
Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus
(Molecular Phylogenetics and Evolution, 2009-08-01) [Artigo]
Paracoccidioidomycosis (PCM) is a systemic disease endemic to most of Latin America, with greatest impact in rural areas. The taxonomic status of one of the best studied Paracoccidioides isolates (Pb01) as A brasiliensis ...
Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS
(Journal of Neuroimmunology, 2014-03-15) [Artigo]
Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic ...
Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats
(Memórias do Instituto Oswaldo Cruz, 2010-05-01) [Artigo]
Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease. Spontaneous remission is, in part, attributed ...
Analysis of the Virulence of an Atypical Enteropathogenic Escherichia coli Strain In Vitro and In Vivo and the Influence of Type Three Secretion System
(BioMed Research International, 2014-01-01) [Artigo]
Atypical enteropathogenic Escherichia coli (aEPEC) inject various effectors into intestinal cells through a type three secretion system (T3SS), causing attaching and effacing (A/E) lesions. We investigated the role of T3SS ...
Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity
(Current Pharmaceutical Biotechnology, 2013-10-01) [Artigo]
Cyanobacteria are an important source of structurally bioactive metabolites, with cytotoxic, antiviral, anticancer, antimitotic, antimicrobial, specific enzyme inhibition and immunosuppressive activities. This study focused ...
Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from a Brazilian university hospital
(Brazilian Journal of Infectious Diseases, 2014-05-01) [Artigo]
The aim of this study was to perform SCCmec typing in Staphylococcus aureus isolates and to characterize the clonal profile of these isolates. Forty-six mecA gene-positive strains isolated between 2002 and 2006 were submitted ...