Geração de trombina em cães com doença renal crônica proteinúrica
Carregando...
Data
2019-05-17
Autores
Gonçalves, Daniele Silvano
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
Cães com doença renal crônica (DRC) apresentam risco de eventos tromboembólicos, porém o mecanismo que leva à hipercoagulabilidade e ao risco na população de cães é desconhecido. O objetivo deste trabalho foi avaliar as possíveis tendências trombóticas e sua correlação com o estadiamento da DRC em cães. Trata-se de um estudo observacional transversal de casos-controle de cães atendidos no Hospital Veterinário da FMVZ – UNESP, com sinais clínicos compatíveis com DRC. Os animais incluídos neste estudo foram cães de tutores voluntários, com diagnóstico de DRC proteinúrica (n=19) e animais saudáveis (n=20). Foram avaliados hemograma, perfil bioquímico renal, hepático, lipídico e proteínas, urinálise e razão proteína/creatinina urinária, fibrinogênio, TP, TTPa, tromboelastometria (TEM) e o teste de geração de trombina (TGT). Não houve diferença na geração de trombina entre os grupos, refutando a hipótese de que a geração de trombina contribui para o estado de hipercoagulabilidade em cães com DRC e proteinúria. O fibrinogênio aumentado é o principal achado encontrado em cães com DRC, corroborando com os achados de hiercoagulabilidade na TEM. Estudos adicionais são necessários para explorar uma possível contribuição da trombogenicidade para as manifestações clínicas da DRC.
Dogs with chronic kidney disease (CKD) are at risk thromboembolic events, but the mechanism leading to hypercoagulability and the population of dogs at risk are unknown. The aim of this study is to evaluate the possible thrombotic tendencies and their correlation with the staging of CKD in dogs. This is a observational cross-section study of client-owned dogs presented to Small Animal Clinical Service at the School of Veterinary Medicine and Animal Science of São Paulo State University, with clinical signs compatible with proteinuric CKD. The animals included this study were client-owned dogs with a diagnosis of proteinuric CKD (n=19) and healthy case-matched controls (n=20). Complete blood counts, renal, hepatic, lipidic and proteins serum biochemistry profile, urinalysis and urinary ratio protein/creatinine, fibrinogen, PT, aPTT, and thrombin generation test were evaluated. There was no difference in generation of thrombin between groups, refuting the hypothesis that thrombin generation is required for the state of hypercoagulability in dogs with CKD and proteinuria. Increased fibrinogen is the main finding found in dogs with CKD, corroborating with the findings of hypercoagulability in thromboelastometry. Studies are mandatory for the evaluation of thrombogenicity for clinical manifestations of DRC.
Dogs with chronic kidney disease (CKD) are at risk thromboembolic events, but the mechanism leading to hypercoagulability and the population of dogs at risk are unknown. The aim of this study is to evaluate the possible thrombotic tendencies and their correlation with the staging of CKD in dogs. This is a observational cross-section study of client-owned dogs presented to Small Animal Clinical Service at the School of Veterinary Medicine and Animal Science of São Paulo State University, with clinical signs compatible with proteinuric CKD. The animals included this study were client-owned dogs with a diagnosis of proteinuric CKD (n=19) and healthy case-matched controls (n=20). Complete blood counts, renal, hepatic, lipidic and proteins serum biochemistry profile, urinalysis and urinary ratio protein/creatinine, fibrinogen, PT, aPTT, and thrombin generation test were evaluated. There was no difference in generation of thrombin between groups, refuting the hypothesis that thrombin generation is required for the state of hypercoagulability in dogs with CKD and proteinuria. Increased fibrinogen is the main finding found in dogs with CKD, corroborating with the findings of hypercoagulability in thromboelastometry. Studies are mandatory for the evaluation of thrombogenicity for clinical manifestations of DRC.
Descrição
Palavras-chave
Hipercoagulabilidade, Proteinúria, Trombose, Coagulação, Hypercoagulability, Thrombosis, Coagulation