Now showing items 1-10 of 49
Chemically induced immunotoxicity in a medium-term multiorgan bioassay for carcinogenesis with Wistar rats
(Toxicology and Applied Pharmacology, 2004-01-15) [Artigo]
A variety of chemicals can adversely affect the immune system and influence tumor development. The modifying potential of chemical carcinogens on the lymphoid organs and cytokine production of rats submitted to a medium-term ...
Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA
(Teratogenesis Carcinogenesis and Mutagenesis, 2002-03-06) [Artigo]
Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis (Comet) assay. The highest ...
Effects of diuron on toxicological and hematological parameters and lymphohematopoietic organs in a rat chemical hepatocarcinogenesis model
(Annual Review of Biomedical Sciences, 2005) [Artigo]
Effects of fasting and intermittent fasting on rat hepatocarcinogenesis induced by diethylnitrosamine
(Teratogenesis Carcinogenesis and Mutagenesis, 2002-01-01) [Artigo]
The influences of fasting on DEN-initiation and of intermittent fasting (IF) on the rat liver chemical carcinogenesis process were evaluated in a 52-week long assay. Three groups of adult male Wistar rats were used: Groups ...
Probiotic Enterococcus faecium CRL 183 inhibit chemically induced colon cancer in male Wistar rats
(European Food Research and Technology, 2008-12-01) [Artigo]
Several animal studies have shown that supplementation with specific strains of lactic acid bacteria could prevent the establishment, growth, and metastasis of transplantable and chemically induced tumors. The goal of this ...
Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats
(Cancer Letters, 2000-04-28) [Artigo]
The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% ...
Diuron lacks promoting potential in a rat liver bioassay
(Toxicologic Pathology, 2007-01-01) [Artigo]
The promoting activity of the herbicide Diuron was evaluated in a medium-term rat liver carcinogenesis bioassay that uses as endpoint immunohistochemically identified glutathione S-transferase positive (GST-P+) foci. Male ...
Infiltrating CD8(+) T lymphocytes, natural killer cells, and expression of IL-10 and TGF-beta 1 in chemically induced neoplasms in male Wistar rats
(Toxicologic Pathology, 2004-09-01) [Artigo]
The present study aimed to estimate the number of CD8(+) T and natural killer (NK) infiltrating cells and the expression of interleukin-10 (IL-10) and transforming growth factor beta 1 (TGF-beta1) in chemically induced ...
Screening for In Vitro and In Vivo Antitumor Activities of the Mushroom Agaricus Blazei
(Nutrition and Cancer-an International Journal, 2009-01-01) [Artigo]
We have investigated the in vitro antitumor activity of the mushroom Agaricus blazei Murill on human cancer cell lines as well as its potential anticancer activity in a model of rat colon carcinogenesis. The in vitro ...
Chronic ethanol intake promotes double gluthatione S-transferase transforming growth factor-alpha-positive hepatocellular lesions in male Wistar rats
(Cancer Science, 2008-02-01) [Artigo]
The chronic ethanol intake influence on the gluthatione S-transferase (GST-P) and transforming growth factor alpha (TGF-alpha) expression in remodeling/persistent preneoplastic lesions (PNLs) was evaluated in the resistant ...