Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
Nenhuma Miniatura disponível
Data
2019-08-01
Autores
Forcato, Simone
Montagnini, Bruno Garcia
Marino de Goes, Maria Luiza
Barrionuevo da Silva Novi, Daniella Regina
Inhasz Kiss, Ana Carolina
Ceravolo, Graziela Scalianti
Ceccatto Gerardin, Daniela Cristina
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Metformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development.
Descrição
Palavras-chave
Antidiabetic drug, Maternal exposure, Estrous cycle
Como citar
Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 87, p. 1-7, 2019.