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dc.contributor.authorKun, Roland S.
dc.contributor.authorGomes, Ana Carolina S. [UNESP]
dc.contributor.authorHildén, Kristiina S.
dc.contributor.authorSalazar Cerezo, Sonia
dc.contributor.authorMäkelä, Miia R.
dc.contributor.authorde Vries, Ronald P.
dc.identifier.citationBiotechnology Advances, v. 37, n. 6, 2019.
dc.description.abstractFungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. In this review, the main approaches for strain engineering of filamentous fungi in the field of plant biomass degradation will be discussed, including recent and not yet implemented methods, such as CRISPR/Cas9 genome editing and adaptive evolution.en
dc.description.sponsorshipMinistry of Economic Affairs
dc.description.sponsorshipAcademy of Finland
dc.description.sponsorshipNederlandse Organisatie voor Wetenschappelijk Onderzoek
dc.relation.ispartofBiotechnology Advances
dc.subjectAdaptive evolution
dc.subjectChemical mutagenesis
dc.subjectGenetic engineering
dc.subjectGenome editing
dc.subjectUV mutagenesis
dc.titleDevelopments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradationen
dc.contributor.institutionUtrecht University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Helsinki
dc.description.affiliationFungal Physiology Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology Utrecht University, Uppsalalaan 8
dc.description.affiliationInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), Cristóvão Colombo
dc.description.affiliationFungal Genetics and Biotechnology Department of Microbiology University of Helsinki, Viikinkaari 9
dc.description.affiliationUnespInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), Cristóvão Colombo
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdMinistry of Economic Affairs: 15807
dc.description.sponsorshipIdAcademy of Finland: 297847
dc.description.sponsorshipIdAcademy of Finland: 308284
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