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dc.contributor.authorFumagalli, Fernando
dc.contributor.authorde Melo, Shaiani Maria Gil
dc.contributor.authorRibeiro, Camila Maríngolo [UNESP]
dc.contributor.authorSolcia, Mariana Cristina [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorda Silva Emery, Flavio [UNESP]
dc.date.accessioned2019-10-06T16:17:57Z
dc.date.available2019-10-06T16:17:57Z
dc.date.issued2019-04-15
dc.identifierhttp://dx.doi.org/10.1016/j.bmcl.2019.02.019
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, v. 29, n. 8, p. 974-977, 2019.
dc.identifier.issn1464-3405
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/11449/188746
dc.description.abstractIdentification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo[2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a C–H amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo[2,3-b]pyridine core through this reaction.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent974-977
dc.language.isoeng
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.sourceScopus
dc.subjectAntibiotic
dc.subjectC–H activation
dc.subjectFuropyridine
dc.subjectMultidrug-resistant
dc.subjectTuberculosis
dc.titleExploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosisen
dc.typeArtigo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (FCFRP-USP), Av. do Café s/n° – Campus Universitário da USP
dc.description.affiliationDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú km01, s/n, Campos Ville
dc.description.affiliationUnespDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú km01, s/n, Campos Ville
dc.identifier.doi10.1016/j.bmcl.2019.02.019
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85061783343
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