Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus
Nenhuma Miniatura disponível
Data
2011-07-01
Autores
Bassetto, C. C. [UNESP]
Silva, B. F. [UNESP]
Newlands, G. F. J.
Smith, W. D.
Amarante, Alessandro Francisco Talamini do [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Wiley-Blackwell
Resumo
A vaccine containing integral membrane glycoproteins from the intestine of Haemonchus contortus was evaluated in four groups of nine worm-free calves challenged with either 8000 H. contortus or Haemonchus placei infective larvae. Vaccinates received 50 mu g of the antigen and 1 mg QuilA adjuvant three times 21 days apart, while the controls got adjuvant alone. The calves were challenged 7 days after the last immunization and killed for worm counts 43 days later. Immunization resulted in high titre antibodies against the vaccine antigens and significant reduction in egg output and worm numbers of both challenge species, compared with control calves. It was concluded that vaccination of calves with native parasite gut membrane glycoproteins obtained from H. contortus conferred protection against both H. placei and H. contortus.
Descrição
Palavras-chave
cattle, Haemonchus contortus, Haemonchus placei, parasitic gastroenteritis, vaccine
Como citar
Parasite Immunology. Malden: Wiley-blackwell, v. 33, n. 7, p. 377-381, 2011.