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dc.contributor.authorPagan, Luana U. [UNESP]
dc.contributor.authorDamatto, Ricardo L.
dc.contributor.authorGomes, Mariana J. [UNESP]
dc.contributor.authorLima, Aline R. R. [UNESP]
dc.contributor.authorCezar, Marcelo D. M.
dc.contributor.authorDamatto, Felipe C. [UNESP]
dc.contributor.authorReyes, David R. A. [UNESP]
dc.contributor.authorCaldonazo, Tulio M. M. [UNESP]
dc.contributor.authorPolegato, Bertha F. [UNESP]
dc.contributor.authorOkoshi, Marina P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.date.accessioned2019-10-06T16:50:15Z
dc.date.available2019-10-06T16:50:15Z
dc.date.issued2019-01-01
dc.identifierhttp://dx.doi.org/10.1111/jcmm.14530
dc.identifier.citationJournal of Cellular and Molecular Medicine, v. 23, n. 9, p. 6504-6507, 2019.
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/11449/189726
dc.description.abstractWe evaluated the influence of aerobic training on cardiac remodeling in untreated spontaneously hypertensive rats (SHR). Four experimental groups were used: sedentary (W-SED, n=27) and trained (WEX, n=31) normotensive Wistar rats, and sedentary (SHR-SED, n=27) and exercised (SHR-EX, n=32) hypertensive rats. At 13 months old, trained groups underwent treadmill exercise five days a week for four months. Statistical analysis: ANOVA or Kruskal-Wallis. Exercised groups had higher physical capacity. Hypertensive groups presented left ventricular (LV) concentric hypertrophy with impaired function. Left atrium diameter, LV posterior wall thickness and relative thickness, and isovolumetric relaxation time were lower in SHR-EX than SHR-SED. Interstitial collagen fraction and Type I-Type III collagen ratio were higher in SHR-SED than W-SED. In SHR-EX these parameters had intermediate values between W-EX and SHRSED with no differences between either group. Myocardial matrix metalloproteinase-2 activity, evaluated by zymography, was higher in SHR-SED than W-SED and SHR-EX. TIMP-2 was higher in hypertensive than normotensive groups. In conclusion, low intensity aerobic exercise reduces left atrium dimension and LV posterior wall thickness, and improves functional capacity, diastolic function, and metalloproteinase-2 activity in adult SHR.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.format.extent6504-6507
dc.language.isoeng
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.sourceScopus
dc.subjectarterial hypertension
dc.subjectmetalloproteinase
dc.subjectmyocardial fibrosis
dc.subjectTIMP
dc.titleLow-intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive ratsen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFAIT
dc.description.affiliationBotucatu Medical School UNESP Sao Paulo State University
dc.description.affiliationItapeva Social and Agrarian Sciences College FAIT
dc.description.affiliationUnespBotucatu Medical School UNESP Sao Paulo State University
dc.identifier.doi10.1111/jcmm.14530
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2014/00747-1
dc.description.sponsorshipIdFAPESP: 2015/17539-5
dc.description.sponsorshipIdCNPq: 308557/2018-2
dc.description.sponsorshipIdCNPq: 310876/2018-4
dc.identifier.scopus2-s2.0-85071289798
unesp.author.lattes4563764623232492[9]
unesp.author.orcid0000-0001-7728-4505[10]
unesp.author.orcid0000-0002-2875-9532[9]
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