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dc.contributor.authorFaine, L. A.
dc.contributor.authorRodrigues, H. G.
dc.contributor.authorGalhardi, C. M.
dc.contributor.authorEbaid, GMX
dc.contributor.authorDiniz, Y. S.
dc.contributor.authorFernandes, AAH
dc.contributor.authorNovelli, ELB
dc.date.accessioned2014-05-20T13:53:17Z
dc.date.available2014-05-20T13:53:17Z
dc.date.issued2006-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.etp.2005.10.001
dc.identifier.citationExperimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 57, n. 3, p. 221-226, 2006.
dc.identifier.issn0940-2993
dc.identifier.urihttp://hdl.handle.net/11449/19007
dc.description.abstractRecent lines of evidences indicate that several pathological conditions, as cardiovascular diseases, are associated with oxidative stress. In order to validate a butylated hydroxytoluene (BHT)-induced experimental model of oxidative stress in the cardiac tissue and serum lipids, 12 Wistar rats were divided into two groups, a control group and the BHT group, Which received BHT i.p. twice a week (1500 mg/kg body Weight) during 30 days. BHT group presented lower body weight gain and heart weight. BHT induced toxic effects on serum through increased triacylglycerols (TG), VLDL and LDL-cholesterol concentrations. The heart of BHT animals showed alteration of antioxidant defenses and increased concentrations of lipid hydroperoxides, indicating elevated lipoperoxidation. TG concentrations and lactate dehydrogenase activities were elevated in the cardiac Muscle of BHT animals. Thus, long-term administration of BHT is capable to induce oxidative and metabolic alterations similarly to some pathological disorders, constituting an efficient experimental model to health scientific research. (c) 2005 Elsevier GrnbH. All rights reserved.en
dc.format.extent221-226
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.sourceWeb of Science
dc.subjectbutylatcd hydroxytoluenept
dc.subjectoxidative stresspt
dc.subjectheartpt
dc.subjectenergy metabolismpt
dc.subjectserum lipidspt
dc.subjectcholesterolpt
dc.subjecttriacylglycerolspt
dc.subjectlipid peroxidationpt
dc.subjectantioxidant enzymespt
dc.titleButyl hydroxytoluene (BHT)-induced oxidative stress: Effects on serum lipids and cardiac energy metabolism in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State Uiv, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Uiv, UNESP, Fac Med, Post Grad Course, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Uiv, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Uiv, UNESP, Fac Med, Post Grad Course, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.etp.2005.10.001
dc.identifier.wosWOS:000235892600005
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.author.orcid0000-0002-6122-0379[2]
unesp.author.orcid0000-0001-8741-1336[3]
dc.relation.ispartofjcr2.023
dc.relation.ispartofsjr0,551
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