A nanoscale redox-active composite as a low-fouling interface for capacitive assaying
Nenhuma Miniatura disponível
Data
2019-07-15
Autores
Fernandes, Flávio C. Bedatty [UNESP]
Andrade, Juliana R. [UNESP]
Bueno, Paulo R. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
An electro-active nanoscale composite was engineered to serve as an alternative to monolayers in a capacitive biosensing platform. An electrochemical impedance-derived spectroscopic method was applied to analyse the response of this nanoscale (c.a. 9 nm thickness) composite to detect C-reactive protein. The composite was successfully assembled over a conductive electrode and built up by conjugating graphene oxide sheets into a self-assembled 11-ferrocenyl-undecanethiol structure, forming a molecular composite concomitantly coated with zwitterionic methacrylate-based monomers that served as the non-fouling component of the composite. Finally, the functionalization of a composite with receptors allowed the successful testing of its electro-analytical ability to detect C-reactive protein in both phosphate-buffered saline and neat human serum samples.
Descrição
Palavras-chave
Electrochemical impedance spectroscopy, Immittance function electro-analysis, Low-fouling, Nanoscale composite, Zwitterionic compound
Como citar
Sensors and Actuators, B: Chemical, v. 291, p. 493-501.