Paracoccidioidomycosis associated with immunosuppression, AIDS, and Cancer
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2018-01-01
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Marques, Silvio Alencar [UNESP]
Shikanai-Yasuda, Maria Aparecida
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This chapter presents clinical, diagnostic, and therapeutic aspects of the mycosis when associated to immunosuppressive conditions. Antifungal therapy proved unsuccessful in patients with severe forms of paracoccidioidomycosis indicating that in addition to treatment of the underlying disease, these patients should also receive a long course of antifungal therapy. Most of the neoplasias associated to paracoccidioidomycosis were carcinomas. The association paracoccidioidomycosis and cancer is an important one which should be approached from a multidisciplinary point of view in order to further contribute to the knowledge of the host-parasite relationship in paracoccidioidomycosis. An interpretation of the low antibody titers detect in AIDS-associated paracoccidioidomycosis may be given by the immunopathogenesis of HIV infection. In AIDS patients, although B cells proliferate and show polyclonal activation, they have a defect in their ability to secrete antigen-specific immunoglobulins. AIDS-associated paracoccidioidomycosis should be considered a real and serious complications which presents new challenges to clinicians and investigators living in endemic countries.
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Paracoccidioidomycosis, p. 393-405.