Desenvolvimento de metodologia para uso de betaterapia intraoperatória em medicina veterinária
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Data
2020-05-21
Autores
Vettorato, Michel de Campos [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A betaterapia é uma modalidade dentro da braquiterapia que utiliza aplicadores de radiação beta, os quais são usados no tratamento de lesões superficiais. Com o avanço das técnicas terapêuticas, novos protocolos clínicos da medicina veterinária serão estabelecidos. Neste sentido, a betaterapia surge como uma opção importante para a realização de procedimentos radioterápicos e consequentente haverá estudos para definições de protocolos clínicos oncológicos. Neste trabalho é apresentada uma metodologia para determinação da distribuição de dose de radiação beta proveniente de aplicadores de estrôncio-90 (Sr90), para uso em radioterapia intraoperatória em medicina veterinária. Foram analisadas as distribuições de dose de radiação planar de três aplicadores de Sr90, por meio de filmes radiográficos, os quais foram expostos aos feixes oriundos das fontes em diferentes tempos de exposição. Foi verificada a densidade óptica (D.O.) do campo de radiação por um densitômetro digital. Após o escaneamento dos filmes, com o uso do software ImageJ, foram medidas as intensidades de brilho referente aos campos de exposição da radiação. A análise da distribuição de dose de radiação dos aplicadores de betaterapia, produziu resultados semelhantes aos apresentados na literatura. O uso do software ImageJ, assim como a D.O. obtida auxiliaram na análise dos estudos dosimétricos. Os comportamentos das curvas de dose-efeito proporcionaram maior compreensão da homogeneidade do campo de radiação no plano de tratamento, deste modo, as distribuições da dose de radiação nos campos de tratamento indicam o uso destes tipos de aplicadores nos procedimentos de radioterapia veterinária.
Beta therapy is a modality within brachytherapy that utilizes beta radiation applicators, which are used in the treatment of superficial injuries. The advance of radiotherapy techniques allows the establishment of new clinical protocols of veterinary medicine will be established. Beta therapy appears as an important option for performing radiotherapy procedures and, consequently, there will be studies for the definition of clinical oncological protocols. This study presents a methodology for determining the dose distribution of beta radiation from strontium90 applicators (Sr90) for use in intraoperative radiotherapy in veterinary medicine. The planar radiation dose distributions of three Sr90 applicators were analyzed by radiographic films, to which they were exposed to beams from sources at different exposure times. The optical density (O.D.) of the radiation field was verified by a digital densitometer. After scanning the films, ImageJ software measured the brightness intensity of the radiation exposure fields. The radiation dose distribution analysis of the beta therapy applicators produced results similar to those presented in the literature. The use of ImageJ software, as well as O.D. obtained helped in the analysis of dosimetric studies. The behaviors of the dose-effect curves provided a better understanding of the radiation field homogeneity in the treatment plan, thus, the radiation dose distributions in the treatment fields indicate the use of these types of applicators in veterinary radiotherapy procedures.
Beta therapy is a modality within brachytherapy that utilizes beta radiation applicators, which are used in the treatment of superficial injuries. The advance of radiotherapy techniques allows the establishment of new clinical protocols of veterinary medicine will be established. Beta therapy appears as an important option for performing radiotherapy procedures and, consequently, there will be studies for the definition of clinical oncological protocols. This study presents a methodology for determining the dose distribution of beta radiation from strontium90 applicators (Sr90) for use in intraoperative radiotherapy in veterinary medicine. The planar radiation dose distributions of three Sr90 applicators were analyzed by radiographic films, to which they were exposed to beams from sources at different exposure times. The optical density (O.D.) of the radiation field was verified by a digital densitometer. After scanning the films, ImageJ software measured the brightness intensity of the radiation exposure fields. The radiation dose distribution analysis of the beta therapy applicators produced results similar to those presented in the literature. The use of ImageJ software, as well as O.D. obtained helped in the analysis of dosimetric studies. The behaviors of the dose-effect curves provided a better understanding of the radiation field homogeneity in the treatment plan, thus, the radiation dose distributions in the treatment fields indicate the use of these types of applicators in veterinary radiotherapy procedures.
Descrição
Palavras-chave
Metodologia, Radioterapia Veterinária, Betaterapia Intraoperatória, Methodology, Veterinary radiotherapy, Intraoperative betatherapy