Efeitos hemodinâmicos, respiratórios e hemogasométricos da infusão contínua de nalbufina em cadelas anestesiadas com sevofluorano
Data
2020-08-21
Autores
Siqueira, Carlos Eduardo de
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Universidade Estadual Paulista (Unesp)
Resumo
Com o estudo objetivou-se avaliar os efeitos da infusão contínua de nalbufina sobre as variáveis hemodinâmicas, respiratórias e hemogasométricas em cães submetidos a anestesia pelo sevofluorano. Foram utilizadas 18 cadelas, com média de 2 ± 1 anos, não castradas, com peso médio de 10 ± 4 kg. Os animais foram distribuídos em dois grupos de 9 animais cada, denominados grupo nalbufina (GN) e grupo controle (GC) e induzidos à anestesia com sevofluorano, intubados e conectados ao circuito anestésico, ajustando-se o sevofluorano para manutenção da anestesia. Após 15 minutos e antes da administração do opioide ou solução fisiológica, procedeu-se a colheita das variáveis no momento basal (MB) e foi administrado bolus de nalbufina (0,3 mg/kg), seguido da infusão continua (0,4 mg/kg/hora). No GC substituiu-se o opioide pela solução de NaCl 0,9%, em volumes idênticos em bolus e infusão, ambos administrados pela via intravenosa. As variáveis hemodinâmicas e cardiorrespiratórias tiveram início antes da administração do opioide ou NaCl 0,9% (MB) e 20, 40, 60 e 80 minutos após o início da infusão contínua (M20, M40, M60 e M80 respectivamente). Já as variáveis hemogasométricas foram coletadas no momento basal, 40 e 80 minutos após o início da infusão (MB, M40 e M80, respectivamente). Houve aumento dos valores de IED e PaO2 do GN e do pH do GC. Observou-se redução do EtCO2 e TC em ambos os grupos e da PaCO2 no GC. Diferença significativa do EtSEVO no M40 (24,1%) e M60 (14,2%) foi observada entre os grupos. Com base nos resultados obtidos, conclui-se que a infusão contínua de nalbufina em cães hígidos anestesiados com sevofluorano, na dose empregada, reduz o requerimento anestésico de sevofluorano e não promove alterações hemodinâmicas, respiratórias e hemogasométricas clinicamente importantes, podendo ser usada com segurança para a espécie.
The objective of this study was to evaluate the effects of continuous infusion of nalbuphine on hemodynamic, respiratory and hemogasometric variables in dogs submitted to sevoflurane anesthesia. There will be 18 female dogs, age 2 ± 1 years old, not castrated, weighing 10 ± 4 kg. The animals will be distributed in two groups of 9 animals each, denominated nalbuphine group (NG) and control group (CG), and will be induced to anesthesia with sevoflurane, intubated and connected to the anesthetic circuit, where the sevoflurane will be adjusted to maintain the anesthesia. After 15 minutes and before administration of the opioid or physiological solution, the variables will be collected at baseline (MB) and nalbuphine bolus (0.3 mg / kg), followed by continuous infusion (0.4 mg / kg / hr). In the CG the opioid was replacing with the 0.9% NaCl solution, in identical bolus and infusion volumes, both administered intravenously. The observations of hemodynamic and cardiorespiratory variables will begin before administration of opioid or NaCl 0.9% (MB) and 20, 40, 60 and 80 minutes after starting continuous infusion (M20, M40, M60 and M80 respectively). The hemogasometric variables will be collected at baseline, 40 and 80 minutes after infusion (MB, M40 and M80, respectively). There was an increase in the DEI and PaO2 values of the NG and the pH of the CG. A reduction in EtCO2 and CT was observed in both groups and in PaCO2 in the CG. Significant difference in EtSEVO in M40 (24,1%) and M60 (14,2%) was observed between groups. Based on the results obtained, it is concluded that the continuous infusion of nalbuphine in healthy dogs anesthetized with sevofluorane, at the dose used, reduces the anesthetic requirement of sevofluorane and does not promote clinically important hemodynamic, respiratory and blood gas changes and can be used to safety for this specie.
The objective of this study was to evaluate the effects of continuous infusion of nalbuphine on hemodynamic, respiratory and hemogasometric variables in dogs submitted to sevoflurane anesthesia. There will be 18 female dogs, age 2 ± 1 years old, not castrated, weighing 10 ± 4 kg. The animals will be distributed in two groups of 9 animals each, denominated nalbuphine group (NG) and control group (CG), and will be induced to anesthesia with sevoflurane, intubated and connected to the anesthetic circuit, where the sevoflurane will be adjusted to maintain the anesthesia. After 15 minutes and before administration of the opioid or physiological solution, the variables will be collected at baseline (MB) and nalbuphine bolus (0.3 mg / kg), followed by continuous infusion (0.4 mg / kg / hr). In the CG the opioid was replacing with the 0.9% NaCl solution, in identical bolus and infusion volumes, both administered intravenously. The observations of hemodynamic and cardiorespiratory variables will begin before administration of opioid or NaCl 0.9% (MB) and 20, 40, 60 and 80 minutes after starting continuous infusion (M20, M40, M60 and M80 respectively). The hemogasometric variables will be collected at baseline, 40 and 80 minutes after infusion (MB, M40 and M80, respectively). There was an increase in the DEI and PaO2 values of the NG and the pH of the CG. A reduction in EtCO2 and CT was observed in both groups and in PaCO2 in the CG. Significant difference in EtSEVO in M40 (24,1%) and M60 (14,2%) was observed between groups. Based on the results obtained, it is concluded that the continuous infusion of nalbuphine in healthy dogs anesthetized with sevofluorane, at the dose used, reduces the anesthetic requirement of sevofluorane and does not promote clinically important hemodynamic, respiratory and blood gas changes and can be used to safety for this specie.
Descrição
Palavras-chave
Opioides, Cães, Infusões intravenosas, Ecocardiografia, Anestésicos, Opioids, Dogs, Intravenous infusions, Echocardiography, Anesthetics