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Molecular models for shikimate pathway enzymes of Xylella fastidiosa
(Biochemical and Biophysical Research Communications, 2004-07-30) [Artigo]
The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. ...
Structural basis for inhibition of human PNP by immucillin-H
(Biochemical and Biophysical Research Communications, 2003-10-03) [Artigo]
Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. PNP is a target for inhibitor development aiming at T-cell immune response modulation. ...
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Biochemical and Biophysical Research Communications, 2004-01-23) [Artigo]
Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent ...
New catalytic mechanism for human purine nucleoside phosphorylase
(Biochemical and Biophysical Research Communications, 2005-02-18) [Artigo]
Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Recently, several structures of human PNP have been ...
Structural bioinformatics study of PNP from Schistosoma mansoni
(Biochemical and Biophysical Research Communications, 2004-09-10) [Artigo]
The parasite Schistosoma mansoni lacks the de novo pathway for purine biosynthesis and depends on salvage pathways for its purine requirements. Schistosomiasis is endemic in 76 countries and territories and amongst the ...
Factors regulating diversity and abundance of fish communities in Pantanal lagoons, Brazil
(Fisheries Management and Ecology, 2004-02-01) [Artigo]
The factors effecting fish species richness, evenness and relative abundance in 19 floodplain lagoons in the Pantanal (Brazil) were examined. Richness and evenness were strongly correlated with the lagoon's: (i) isolation ...
Depression in patients with Parkinson's disease: Impact on functioning
(Journal of the Neurological Sciences, 2008-09-15) [Artigo]
Depression is a frequently observed neuropsychiatric phenomenon in Parkinson's disease (PD) and it has been lately considered as a manifestation of such disease. The aim of the study was to investigate the relationship ...
A preliminary study of insect fauna on pig carcasses located in sugarcane in winter in southeastern Brazil
(Medical and Veterinary Entomology, 2009-06-01) [Artigo]
Minimum post-mortem intervals can be estimated based on analyses of the pattern of insect succession on a carcass. In order to successfully apply this approach, insect development rates must be considered with regard to ...
Intriguing evidence of translocations in Discus fish (Symphysodon, Cichlidae) and a report of the largest meiotic chromosomal chain observed in vertebrates
(Heredity, 2009-05-01) [Artigo]
As part of a program to understand the genetics of Amazonian ornamental fish, classical cytogenetics was used to analyze Symphysodon aequifasciatus, S. discus and S. haraldi, popular and expensive aquarium fishes that are ...
Vertebrate dispersal syndromes along the Atlantic forest: broad-scale patterns and macroecological correlates
(Global Ecology and Biogeography, 2008-07-01) [Artigo]
Aim To assess the geographical variation in the relative importance of vertebrates, and more specifically of birds and mammals, as seed dispersal agents in forest communities, and to evaluate the influence of geographical ...