Lipase-oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec-alcohols
Nenhuma Miniatura disponível
Data
2020-05-20
Autores
De Almeida, Laiza A. [UNESP]
Marcondes, Thayna H. [UNESP]
Milagre, Cintia D. F. [UNESP]
Milagre, Humberto M. S. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Herein, we present a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL−B/VOSO4 system at 50 °C in the relatively green solvent heptane. This catalytic system is active and chemo- and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcohols were evaluated to determine the substrate scope. The performance of the combined CAL−B/VOSO4 system was improved by employing a low-cost, homemade Teflon tube to compartmentalize the catalysts in one-pot conditions, making this system for up to 8 reaction cycles.
Descrição
Palavras-chave
dynamic kinetic resolution, heterogeneous catalysis, lipase, sec-alcohols, vanadium
Como citar
ChemCatChem, v. 12, n. 10, p. 2849-2858, 2020.