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dc.contributor.authorOliveira, Rodrigo Juliano
dc.contributor.authorBaise, Evelyn
dc.contributor.authorMauro, Mariana de Oliveira
dc.contributor.authorPesarini, Joao Renato
dc.contributor.authorMatuo, Renata
dc.contributor.authorda Silva, Ariane Fernanda
dc.contributor.authorRibeiro, Lucia Regina [UNESP]
dc.contributor.authorMantovani, Mario Sergio
dc.date.accessioned2014-05-20T13:55:49Z
dc.date.available2014-05-20T13:55:49Z
dc.date.issued2009-07-01
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2009.03.008
dc.identifier.citationEnvironmental Toxicology and Pharmacology. Amsterdam: Elsevier B.V., v. 28, n. 1, p. 120-124, 2009.
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/11449/19991
dc.description.abstractThis research has evaluated the effects of enteral supplementation of glutamine in clastogens and genotoxic damages caused by the acute administration of cisplatin. For this. it was utilized Swiss mice distributed in eight experimental groups: control, cisplatin, glutamine, in three different doses and the combination of these with cisplatin. The results show that the glutamine was present in neither genotoxic nor mutagenic activity. When in association with glutamine and cisplatin, in simultaneous treatment, it was verified the frequency decreased of micronuclei and comets. The damage reduction percentages to the micronucleus ranged from 95.4 to 91.8% after 24 h of administration of these compounds and 76.7 to 56.8% after 48 h. In the same time the damage reduction percentages to the comet test ranged from 117.0 to 115.0%. The results suggest that glutamine is capable of preventing genotoxic and mutagenic damage according to the experimental design proposed. (C) 2009 Elsevier B.V. All rights reserved.en
dc.format.extent120-124
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.sourceWeb of Science
dc.subjectCisplatinen
dc.subjectGlutamineen
dc.subjectMicronucleusen
dc.subjectCometen
dc.subjectChemopreventionen
dc.titleEvaluation of chemopreventive activity of glutamine by the comet and the micronucleus assay in mice's peripheral blooden
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionCtr Univ Filadelfia UniFil
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationCtr Univ Filadelfia UniFil, Dept Nutr, Londrina, PR, Brazil
dc.description.affiliationCtr Univ Filadelfia UniFil, Dept Biomed, Londrina, PR, Brazil
dc.description.affiliationCtr Univ Filadelfia UniFil, CENUGEN Ctr Estudos Nutr & Genet Toxicol, Londrina, PR, Brazil
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Biol Geral, Londrina, PR, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita Filho UN, Programa Posgrad Biol Celular & Mol, Rio Claro, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita Filho UN, Programa Posgrad Biol Celular & Mol, Rio Claro, SP, Brazil
dc.identifier.doi10.1016/j.etap.2009.03.008
dc.identifier.wosWOS:000266709800017
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
dc.relation.ispartofjcr2.776
dc.relation.ispartofsjr0,813
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