Primary intraosseous CD9-positive B-cell lymphoblastic lymphoma of the maxilla affecting a pediatric patient: Immunohistochemical and in situ hybridization analysis
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Data
2020-09-01
Autores
Silveira, Heitor Albergoni [UNESP]
Sousa, Lucas Moura
Silva, Evânio Vilela [UNESP]
Almeida, Lana Kei Yamamoto
Sverzut, Cassio Edvard
Trivellato, Alexandre Elias
León, Jorge Esquiche
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Resumo
Lymphoblastic lymphoma (LBL) is a clinically aggressive disease, representing approximately 2% of all non-Hodgkin lymphoma cases. In the oral and maxillofacial (OMF) region, approximately 39 cases, diagnosed as LBL, acute lymphoblastic leukemia (ALL) or ALL/LBL, have been reported to date. Noteworthy, the CD9 expression, which indicates a poor outcome in ALL, has not been reported in LBL and lymphoblastic neoplasms of the OMF region. Herein, we report an additional maxillary intraosseous B-cell LBL, affecting a 14-year-old girl, which also showed positivity for CD9, Bcl-6 and MUM1/IRF4. Aiming at diagnostic and prognostic criteria, further studies focusing CD9 expression in LBL is recommended.
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Palavras-chave
Acute lymphoblastic leukemia, CD9, Immunohistochemistry, In situ hybridization, Intraosseous lymphoma, Lymphoblastic lymphoma, Oral and maxillofacial region, Pediatric patient
Como citar
Oral Oncology, v. 108.