The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems
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Data
2020-11-15
Autores
Fonseca-Santos, Bruno [UNESP]
Chorilli, Marlus [UNESP]
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Resumo
Neurological disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biological activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurological disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnology-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacological and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clinical trials for some neurological diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurological diseases. Thus, the use of this nutraceutical has shown true for neurological diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain.
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Palavras-chave
Blood–brain barrier, Brain, Nanocarriers, Nanomedicines, Nasal drug delivery, Resveratrol
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International Journal of Pharmaceutics, v. 589.