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dc.contributor.authorCallera, João Carlos [UNESP]
dc.contributor.authorDe Luca, Laurival Antonio [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.date.accessioned2020-12-12T02:40:29Z
dc.date.available2020-12-12T02:40:29Z
dc.date.issued2020-07-13
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2020.134989
dc.identifier.citationNeuroscience Letters, v. 731.
dc.identifier.issn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/11449/201737
dc.description.abstractInjection of muscimol, a GABAA receptor agonist, into the lateral parabrachial nucleus (LPBN) induces 0.3 M NaCl intake in rats. In the present work, we investigated whether such an effect applies to hypertonic (0.3 M) mineral solutions in general or is selective to sodium solutions in a 240 min intake test. Muscimol injection (0.5 nmol/0.2 μL) compared to vehicle injection into the LPBN of adult hydrated rats produced a preferential ingestion of 0.3 M NaCl (25.3 ± 10.2 mL) followed by a 0.3 M NaHCO3 intake (11.7 ± 5.6 mL), with no significant effect on water, KCl and CaCl2 intake. Only the effect of muscimol on NaCl intake (19.0 ± 10.4 mL) persisted in cell-dehydrated rats, with hardly any effect on water or other mineral solutions. The results suggest that the LPBN controls the ingestion of hypertonic NaCl and NaHCO3. They also suggest a selective mechanisms involving the LPBN to check hypertonic sodium intake.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.isoeng
dc.relation.ispartofNeuroscience Letters
dc.sourceScopus
dc.subjectBicarbonate
dc.subjectDehydration
dc.subjectFluid intake
dc.subjectGABA
dc.subjectParabrachial nucleus
dc.subjectReceptors
dc.subjectSodium appetite
dc.titleMineral preference in rats treated with muscimol into the lateral parabrachial nucleusen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry UNESP
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry UNESP
dc.identifier.doi10.1016/j.neulet.2020.134989
dc.identifier.scopus2-s2.0-85084385421
unesp.author.orcid0000-0001-6569-2843[1]
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