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dc.contributor.authorde Moraes, Camila
dc.contributor.authorCamargo, Enilton A.
dc.contributor.authorAntunes, Edson
dc.contributor.authorde Nucci, Gilberto
dc.contributor.authorZanesco, Angelina
dc.identifier.citationComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 147, n. 3, p. 788-792, 2007.
dc.description.abstractA strong association between the benefits of physical exercise on the cardiovascular disease with an improvement of the endothelium-derived relaxing factor production has been consistently shown. The purpose of this study was to evaluate the effect of exercise training associated with high caloric diet in the reactivity of rat mesenteric and aortic rings. Experimental protocol consisted of 4 weeks of high caloric diet consumption previous to 4 weeks of run training (1.2 km/h, 0% grade, in sessions of 60 min, 5 days/week). Concentrations of triglycerides, glucose, insulin and nitrite/nitrate levels were measured and atherogenic index was calculated. Concentration-response curves to acetylcholine (10 nM-100 mu M), sodium nitroprusside (100 pM-100 nM) and phenylephrine (1 nM-3 mu M) were obtained. Exercise training reduced body mass (6%) and triglyceride levels (about 54%), without changes in glucose and insulin concentrations. An improvement of endothelium-dependent relaxation responses to acetylcholine in mesenteric and aortic rings was observed in trained group. No changes were seen for sodium nitroprusside and phenylephrine. In conclusion, our study is the first to show clearly that run training promotes an improvement of the endothelium-dependent relaxing response in aorta and mesenteric rings from rats fed with high caloric diet and that is associated with increase of NO production. (c) 2006 Elsevier B.V. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.sourceWeb of Science
dc.subjectexercise trainingpt
dc.subjecthigh caloric dietpt
dc.subjectvascular reactivitypt
dc.subjectnitric oxidept
dc.titleReactivity of mesenteric and aortic rings from trained rats fed with high caloric dieten
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.description.affiliationUNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Pharmacol, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
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