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dc.contributor.authorTaxini, Camila L. [UNESP]
dc.contributor.authorMarques, Danuzia A.
dc.contributor.authorBícego, Kênia C. [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.date.accessioned2021-06-25T10:58:04Z
dc.date.available2021-06-25T10:58:04Z
dc.date.issued2021-01-01
dc.identifierhttp://dx.doi.org/10.1007/s00424-021-02550-1
dc.identifier.citationPflugers Archiv European Journal of Physiology.
dc.identifier.issn1432-2013
dc.identifier.issn0031-6768
dc.identifier.urihttp://hdl.handle.net/11449/207608
dc.description.abstractThe pontine A5 noradrenergic group contributes to the maturation of the respiratory system before birth in rats. These neurons are connected to the neural network responsible for respiratory rhythmogenesis. In the present study, we investigated the participation of A5 noradrenergic neurons in neonates (P7–8 and P14–15) in the control of ventilation during hypoxia and hypercapnia in in vivo experiments using conjugated saporin anti-dopamine beta-hydroxylase (DβH-SAP) to specifically ablate noradrenergic neurons. Thus, DβH-SAP (420 ng/μL) or saporin (SAP, control) was injected into the A5 region of neonatal male Wistar rats. Hypoxia reduced respiratory variability in control animals; however, A5 lesion prevented this effect in P7–8 rats. Our data suggest that noradrenergic neurons of the A5 region in neonate rats do not participate in the control of ventilation under baseline and hypercapnic conditions, but exert an inhibitory modulation on breathing variability under hypoxic challenge in early life (P7–8).en
dc.language.isoeng
dc.relation.ispartofPflugers Archiv European Journal of Physiology
dc.sourceScopus
dc.subjectBrainstem
dc.subjectCatecholaminergic neurons
dc.subjectDevelopment
dc.subjectHypercapnia
dc.subjectHypoxia
dc.titleA5 noradrenergic neurons and breathing control in neonate ratsen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversité Laval
dc.description.affiliationDepartment of Morphology and Animal Physiology – FCAV São Paulo State University (UNESP), Via de acesso Paulo Donato Castellane s/n
dc.description.affiliationDepartment of Pediatrics Centre de Recherche de L’Institut Universitaire de Cardiologie Et de Pneumologie de Québec Université Laval
dc.description.affiliationUnespDepartment of Morphology and Animal Physiology – FCAV São Paulo State University (UNESP), Via de acesso Paulo Donato Castellane s/n
dc.identifier.doi10.1007/s00424-021-02550-1
dc.identifier.scopus2-s2.0-85104292353
unesp.author.orcid0000-0003-4752-420X[1]
unesp.author.orcid0000-0002-1180-1132[3]
unesp.author.orcid0000-0003-4097-5286[4]
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